Bioinspired Microfluidic Device by Integrating a Porous Membrane and Heterostructured Nanoporous Particles for Biomolecule Cleaning

Jun Bing Fan, Jing Luo, Zhen Luo, Yongyang Song, Zhao Wang, Jingxin Meng, Binshuai Wang, Shudong Zhang, Zijian Zheng, Xiaodong Chen, Shutao Wang

    Research output: Journal article publicationJournal articleAcademic researchpeer-review

    28 Citations (Scopus)


    Mimicking the structures and functions of biological systems is considered as a promising approach to construct artificial materials, which have great potential in energy, the environment, and health. Here, we demonstrate a conceptually distinct design by synergistically combining a kidney-inspired porous membrane and natural sponge-inspired heterostructured nanoporous particles to fabricate a bioinspired biomolecule cleaning device, achieving highly efficient biomolecule cleaning spanning from small molecules to macromolecules. The bioinspired biomolecule cleaning device is a two-layer microfluidic device that integrates a polyamide porous membrane and heterostructured nanoporous poly(acrylic acid)-poly(styrene divinylbenzene) particles. The former as a filtration membrane isolates the upper sample liquid and the latter fixed onto the bottom of the underlying channel acts as an active sorbent, particularly enhancing the clearance of macromolecules. As a proof-of-concept, we demonstrate that typical molecules, including urea, creatinine, lysozyme, and β2-microglobulin, can be efficiently cleaned from simulant liquid and even whole blood. This study provides a method to fabricate a bioinspired biomolecule cleaning device for highly efficient biomolecule cleaning. We believe that our bioinspired synergistic design may expand to other fields for the fabrication of integrated functional devices, creating opportunities in a wide variety of applications.

    Original languageEnglish
    Pages (from-to)8374-8381
    Number of pages8
    JournalACS Nano
    Issue number7
    Publication statusPublished - 23 Jul 2019


    • Bioinspired device
    • Biomolecule cleaning
    • Filtration and adsorption
    • Heterostructured nanoporous particles
    • Porous membrane
    • Synergistic design

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)
    • Physics and Astronomy(all)


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