TY - JOUR
T1 - Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds
AU - Lu, Bitao
AU - Hu, Enling
AU - Ding, Weiwei
AU - Wang, Wenyi
AU - Xie, Ruiqi
AU - Yu, Kun
AU - Lu, Fei
AU - Lan, Guangqian
AU - Dai, Fangyin
N1 - Funding Information:
Funding: This study was supported by the China Agricultural Research System (No. CARS-18-ZJ0102), the Innovation Research 2035 Pilot Plan of Southwest University (SWU-XDPY22010), the National Natural Science Foundation of China (No. 81703424), and the Innovation Project for Graduate Students of Chongqing (CYB21121). Author contributions: B.L.: experimental work, writing, and data analysis. E.H.: writing and data analysis. W.D. and W.W.: animal experiments. R.X., K.Y., and F.L.: calculation and simulation. G.L. and F.D.: theoretical work and project planning. Competing interests: The authors declare that they have no competing interests.
Publisher Copyright:
Copyright © 2023 Bitao Lu et al. Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License (CC BY 4.0).
PY - 2023/5/22
Y1 - 2023/5/22
N2 - Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital settings. Thus, multiple hemostatic strategies are critical for treating large bleeding wounds. In this study, inspired by bombardier beetles to eject toxic spray for defense, a shape-memory aerogel with an aligned microchannel structure was proposed, employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug permeation. Bioinspired aerogels, after contact with blood, can rapidly expand inside the wound, offering robust physical barrier blocking, sealing the bleeding wound, and generating a spontaneous local chemical reaction causing an explosive-like generation of CO2 microbubbles, which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug diffusion. The ejection behavior, drug release kinetics, and permeation capacity were evaluated using a theoretical model and experimentally demonstrated. This novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility, displaying great potential for clinical application in humans.
AB - Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital settings. Thus, multiple hemostatic strategies are critical for treating large bleeding wounds. In this study, inspired by bombardier beetles to eject toxic spray for defense, a shape-memory aerogel with an aligned microchannel structure was proposed, employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug permeation. Bioinspired aerogels, after contact with blood, can rapidly expand inside the wound, offering robust physical barrier blocking, sealing the bleeding wound, and generating a spontaneous local chemical reaction causing an explosive-like generation of CO2 microbubbles, which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug diffusion. The ejection behavior, drug release kinetics, and permeation capacity were evaluated using a theoretical model and experimentally demonstrated. This novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility, displaying great potential for clinical application in humans.
UR - http://www.scopus.com/inward/record.url?scp=85163402511&partnerID=8YFLogxK
U2 - 10.34133/research.0150
DO - 10.34133/research.0150
M3 - Journal article
AN - SCOPUS:85163402511
SN - 2096-5168
VL - 6
JO - Research
JF - Research
M1 - 0150
ER -