Biodegradable microporous starch with assembled thrombin for rapid induction of hemostasis

Qing Li, Fei Lu, Songmin Shang, Hongli Ye, Kun Yu, Bitao Lu, Yang Xiao, Fangyin Dai, Guangqian Lan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)

Abstract

Immediate hemorrhage control is pivotal for saving lives both in civilian life and in the military. In the present study, we developed a three-dimensional carrier based on the enzymolysis of corn starch loaded with thrombin, which efficiently controlled bleeding in a short time. The microporous starch (MS) with a large surface area was modified with sodium trimetaphosphate (STMP) to generate starch phosphate, which showed enhanced thrombin entrapment efficiency. The thrombin-assembled MS-STMP structure (MS-STMP-T) showed excellent hydrophilicity, rapid water absorption, high negative surface charge, and high hemostatic efficiency upon contact with blood in whole blood clotting tests, APTT and PT measurements, and animal injury models. Additionally, MS-STMP-T showed no cytotoxicity and was degraded within 14 days in a rabbit model. These results indicate that MS-STMP-T is a safe and effective agent for the control of bleeding.

Original languageEnglish
Pages (from-to)9121-9132
Number of pages12
JournalACS Sustainable Chemistry and Engineering
Volume7
Issue number10
DOIs
Publication statusPublished - 20 May 2019

Keywords

  • Biocompatibility
  • Biodegradability
  • Hemostasis
  • Microporous starch
  • Thrombin

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment

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