Bioconjugation of luminescent silicon quantum dots for selective uptake by cancer cells

Folarin Erogbogbo, Chen An Tien, Ching Wen Chang, Ken Tye Yong, Wing Cheung Law, Hong Ding, Indrajit Roy, Mark T. Swihart, Paras N. Prasad

Research output: Journal article publicationJournal articleAcademic researchpeer-review

82 Citations (Scopus)

Abstract

Conventional quantum dots have great potential in cancer-related imaging and diagnostic applications; however, these applications are limited by concerns about the inherent toxicity of their core materials (e.g., cadmium, lead). Virtually all imaging applications require conjugation of the imaging agent to a biologically active molecule to achieve selective uptake or binding. Here, we report a study of biocompatible silicon quantum dots covalently attached to biomolecules including lysine, folate, antimesothelin, and transferrin. The particles possess desirable physical properties, surface chemistry, and optical properties. Folate- and antimesothelin-conjugated silicon quantum dots show selective uptake into Panc-1 cells. This study contributes to the preclinical evaluation of silicon quantum dots and further demonstrates their potential as an imaging agent for cancer applications.
Original languageEnglish
Pages (from-to)1081-1088
Number of pages8
JournalBioconjugate Chemistry
Volume22
Issue number6
DOIs
Publication statusPublished - 15 Jun 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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