Bioconjugated pluronic triblock-copolymer micelle-encapsulated quantum dots for targeted imaging of cancer: In vitro and in vivo studies

Liwei Liu, Ken Tye Yong, Indrajit Roy, Wing Cheung Law, Ling Ye, Jianwei Liu, Jing Liu, Rajiv Kumar, Xihe Zhang, Paras N. Prasad

Research output: Journal article publicationJournal articleAcademic researchpeer-review

61 Citations (Scopus)

Abstract

Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of the QD formulation to the tumor site, by exploiting the overexpressed FA receptors (FARs) on the tumor cells. Cytotoxicity study demonstrated that the QD formulation has negligible in vitro toxicity. The in vitro study showed that the bioconjugated micelle-encapsulated QDs, but not the unconjugated QDs, were able to efficiently label Panc-1 cancer cells. In vivo imaging study showed that bioconjugated QDs were able to target tumor site after intravenous injection of the formulation in tumor-bearing mice.
Original languageEnglish
Pages (from-to)705-713
Number of pages9
JournalTheranostics
Volume2
Issue number7
DOIs
Publication statusPublished - 14 Sep 2012
Externally publishedYes

Keywords

  • Bioconjugation
  • Bioimaging
  • Pluronics and Nanotoxicity
  • Quantum dots
  • Targeted delivery

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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