Biocompatibility and bioactivity of hydroxyapatite whiskers reinforced bis-GMA based composites

Hongquan Zhang, Ming Zhang, Yuhui Shen, Haobo Pan, Kuibo Zhang, William W. Lu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

2 Citations (Scopus)


Novel bioactive bis-GMA-based resin composites were successfully developed by incorporating hydroxyapatite (HA) whiskers in the polymeric matrix. The whiskers had good dispersibility and wettability with bis-GMA-based polymer, showing good bonding with the matrix, which conferred good reinforcement. The mechanical properties of the composites were significantly enhanced when compared with the particulate filler. The morphology change of HA did not cause obvious variations in the proliferation and viability of L929 cells and the apatite-forming ability of the composites in SBF. The in vitro cytotoxicity of the composites was depressed by addition of hydroxyapatite filing materials. Such a favorable response indicated an important similarity in surface chemistry of the HA filler, and HA whiskers appeared to have potential as most promising reinforcements for resin-based polymers.
Original languageEnglish
Title of host publicationProceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010
Number of pages5
Publication statusPublished - 1 Dec 2010
Event3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010 - Yantai, China
Duration: 16 Oct 201018 Oct 2010


Conference3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010


  • Apatite-forming ability
  • Hydroxyapatite whiskers
  • In vitro biocompatibility
  • Resin composite

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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