Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

Zhilu Yang, Xin Zhao, Rui Hao, Qiufen Tu, Xiaohua Tian, Yu Xiao, Kaiqing Xiong, Miao Wang, Yonghai Feng, Nan Huang, Guoqing Pan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

41 Citations (Scopus)


Thrombogenic reaction, aggressive smooth muscle cell (SMC) proliferation, and sluggish endothelial cell (EC) migration onto bioinert metal vascular stents make poststenting reendothelialization a dilemma. Here, we report an easy to perform, biomimetic surface engineering strategy for multiple functionalization of metal vascular stents. We first design and graft a clickable mussel-inspired peptide onto the stent surface via mussel-inspired adhesion. Then, two vasoactive moieties [i.e., the nitric-oxide (NO)-generating organoselenium (SeCA) and the endothelial progenitor cell (EPC)-targeting peptide (TPS)] are clicked onto the grafted surfaces via bioorthogonal conjugation. We optimize the blood and vascular cell compatibilities of the grafted surfaces through changing the SeCA/TPS feeding ratios. At the optimal ratio of 2:2, the surface-engineered stents demonstrate superior inhibition of thrombosis and SMC migration and proliferation, promotion of EPC recruitment, adhesion, and proliferation, as well as prevention of in-stent restenosis (ISR). Overall, our biomimetic surface engineering strategy represents a promising solution to address clinical complications of cardiovascular stents and other blood-contacting metal materials.

Original languageEnglish
Pages (from-to)16127-16137
Number of pages11
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number28
Publication statusPublished - 14 Jul 2020


  • EPC capture
  • Mussel adhesive peptide
  • NO generation
  • Surface bioengineering
  • Vascular stents

ASJC Scopus subject areas

  • General

Cite this