Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb

Yi Zhang, Jingya Ruan, Jian Li, Liping Chao, Wen Zhong Shi, Haiyang Yu, Xiumei Gao, Tao Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)

Abstract

The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1–3) and two novel stilbenes (4 and 5), together with six known ones (6–11). Their structures were elucidated on the basis of extensive 1D NMR (1H and13C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6–8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9–11 displayed triglyceride inhibitory effects in HepG2 cells.
Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalFitoterapia
Volume117
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Keywords

  • Diarylheptanoids
  • Dioscorea septemloba Thunb
  • Glucose consumption
  • HepG2 cells
  • L6 cells
  • Stilbenes
  • Triglyceride accumulation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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