Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb

Yi Zhang; Jingya Ruan; Jian Li; Liping Chao; Wen Zhong Shi; Haiyang Yu; Xiumei Gao; Tao Wang

doi:10.1016/j.fitote.2017.01.004

Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb

Yi Zhang, Jingya Ruan, Jian Li, Liping Chao, Wen Zhong Shi, Haiyang Yu, Xiumei Gao, Tao Wang

Research output: Journal article publication › Journal article › Academic research › peer-review

11 Citations (Scopus)

Abstract

The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1–3) and two novel stilbenes (4 and 5), together with six known ones (6–11). Their structures were elucidated on the basis of extensive 1D NMR (1H and13C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6–8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9–11 displayed triglyceride inhibitory effects in HepG2 cells.

Original language	English
Pages (from-to)	28-33
Number of pages	6
Journal	Fitoterapia
Volume	117
DOIs	https://doi.org/10.1016/j.fitote.2017.01.004
Publication status	Published - 1 Mar 2017
Externally published	Yes

Keywords

Diarylheptanoids
Dioscorea septemloba Thunb
Glucose consumption
HepG2 cells
L6 cells
Stilbenes
Triglyceride accumulation

ASJC Scopus subject areas

Pharmacology
Drug Discovery

More information

10.1016/j.fitote.2017.01.004

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title = "Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb",

abstract = "The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1–3) and two novel stilbenes (4 and 5), together with six known ones (6–11). Their structures were elucidated on the basis of extensive 1D NMR (1H and13C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6–8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9–11 displayed triglyceride inhibitory effects in HepG2 cells.",

keywords = "Diarylheptanoids, Dioscorea septemloba Thunb, Glucose consumption, HepG2 cells, L6 cells, Stilbenes, Triglyceride accumulation",

author = "Yi Zhang and Jingya Ruan and Jian Li and Liping Chao and Shi, {Wen Zhong} and Haiyang Yu and Xiumei Gao and Tao Wang",

year = "2017",

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doi = "10.1016/j.fitote.2017.01.004",

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T1 - Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb

AU - Zhang, Yi

AU - Ruan, Jingya

AU - Li, Jian

AU - Chao, Liping

AU - Shi, Wen Zhong

AU - Yu, Haiyang

AU - Gao, Xiumei

AU - Wang, Tao

PY - 2017/3/1

Y1 - 2017/3/1

N2 - The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1–3) and two novel stilbenes (4 and 5), together with six known ones (6–11). Their structures were elucidated on the basis of extensive 1D NMR (1H and13C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6–8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9–11 displayed triglyceride inhibitory effects in HepG2 cells.

AB - The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1–3) and two novel stilbenes (4 and 5), together with six known ones (6–11). Their structures were elucidated on the basis of extensive 1D NMR (1H and13C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6–8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9–11 displayed triglyceride inhibitory effects in HepG2 cells.

KW - Diarylheptanoids

KW - Dioscorea septemloba Thunb

KW - Glucose consumption

KW - HepG2 cells

KW - L6 cells

KW - Stilbenes

KW - Triglyceride accumulation

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U2 - 10.1016/j.fitote.2017.01.004

DO - 10.1016/j.fitote.2017.01.004

M3 - Journal article

C2 - 28065697

SN - 0367-326X

VL - 117

SP - 28

EP - 33

JO - Fitoterapia

JF - Fitoterapia

ER -

Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb

Abstract

Keywords

ASJC Scopus subject areas

More information

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