Binary polymer brush patterns from facile initiator stickiness for cell culturing

Lina Chen, Peng Li, Xi Lu, Shutao Wang, Zijian Zheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)


We report a new initiator stickiness method to fabricate micropatterned binary polymer brush surfaces, which are ideal platforms for studying cell adhesion behavior. The atom transfer radical polymerization (ATRP) initiator, ω-mercaptoundecyl bromoisobutyrate (MUDBr), is found to adsorb on several hosting polymer brushes, including poly[oligo(ethylene glycol)methyl ether methacrylate] (POEGMA), poly(2-hydroxyethyl methacrylate) (PHEMA), and poly(glycidyl methacrylate) (PGMA) brushes. Based on the initiator stickiness, micropatterned initiator molecules are printed onto a layer of homogenous hosting polymer brushes via microcontact printing (μCP), and then, vertically, a patterned second layer of polymer brushes is grown from the initiator areas. With this simple, fast, and additive method, we demonstrate the fabrication of various binary polymer brushes, and show their applications for patterning cell microarrays and controlling cell orientation. This new approach to generating binary polymer brushes shows great potential for the manipulation of interfacial phenomena, facilitating a range of applications from semiconductors and lubrication to fundamental cell biology studies.

Original languageEnglish
Pages (from-to)189-202
Number of pages14
JournalFaraday Discussions
Publication statusPublished - 1 Jan 2019

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry


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