Benzothiazole-substituted benzofuroquinolinium dye: A selective switch-on fluorescent probe for G-quadruplex

Yu Jing Lu, Siu Cheong Yan, Fung Yi Chan, Lan Zou, Wai Hong Chung, Wing Leung Wong, Bin Qiu, Ning Sun, Pak Ho Chan, Zhi Shu Huang, Lian Quan Gu, Kwok Yin Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

62 Citations (Scopus)

Abstract

A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.
Original languageEnglish
Pages (from-to)4971-4973
Number of pages3
JournalChemical Communications
Volume47
Issue number17
DOIs
Publication statusPublished - 7 May 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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