Benzothiazole-substituted benzofuroquinolinium dye: A selective switch-on fluorescent probe for G-quadruplex

Yu Jing Lu; Siu Cheong Yan; Fung Yi Chan; Lan Zou; Wai Hong Chung; Wing Leung Wong; Bin Qiu; Ning Sun; Pak Ho Chan; Zhi Shu Huang; Lian Quan Gu; Kwok Yin Wong

doi:10.1039/c1cc00020a

Benzothiazole-substituted benzofuroquinolinium dye: A selective switch-on fluorescent probe for G-quadruplex

Yu Jing Lu, Siu Cheong Yan, Fung Yi Chan, Lan Zou, Wai Hong Chung, Wing Leung Wong, Bin Qiu, Ning Sun, Pak Ho Chan, Zhi Shu Huang, Lian Quan Gu, Kwok Yin Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

68 Citations (Scopus)

Abstract

A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.

Original language	English
Pages (from-to)	4971-4973
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	17
DOIs	https://doi.org/10.1039/c1cc00020a
Publication status	Published - 7 May 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc00020a

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AU - Lu, Yu Jing

AU - Yan, Siu Cheong

AU - Chan, Fung Yi

AU - Zou, Lan

AU - Chung, Wai Hong

AU - Wong, Wing Leung

AU - Qiu, Bin

AU - Sun, Ning

AU - Chan, Pak Ho

AU - Huang, Zhi Shu

AU - Gu, Lian Quan

AU - Wong, Kwok Yin

PY - 2011/5/7

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AB - A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Benzothiazole-substituted benzofuroquinolinium dye: A selective switch-on fluorescent probe for G-quadruplex

Abstract

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