TY - JOUR
T1 - Baseline health-related quality of life predicts falls
T2 - a secondary analysis of a randomized controlled trial
AU - Davis, Jennifer C.
AU - Hsu, Chun Liang
AU - Ghag, Cheyenne
AU - Starkey, Samantha Y.
AU - Jacova, Patrizio
AU - Dian, Larry
AU - Parmar, Naaz
AU - Madden, Kenneth
AU - Liu-Ambrose, Teresa
N1 - Funding Information:
This work was supported by the Canadian Institutes for Health Research (MOP-110954 and MAT-92025). TLA is a Canada Research Chair (Tier 1) in Healthy Aging. JCD is a Michael Smith Foundation for Health Research Career Scholar and a Canada Research Chair (Tier 2) in Applied Health Economics. The Canadian Institutes for Health Research had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/11
Y1 - 2022/11
N2 - Purpose: Among older adults, health-related quality of life (HRQoL) and falls are associated. Generic patient-reported outcomes measures (PROMs) assess individual’s HRQoL. The role for PROMs, a potential tool for predicting subsequent falls, remains under-explored. Our primary aim was to determine whether a baseline PROMs assessment of HRQoL may be a useful tool for predicting future falls. Methods: A secondary analysis of a 12-month randomized clinical trial (RCT) of a home-based exercise program among 344 adults (67% female), aged ≥ 70 years, with ≥ 1 falls in the prior year who were randomized (1:1) to either a home-based exercise program (n = 172) or usual care (n = 172). A negative binomial regression model with total falls count as the dependent variable evaluated the main effect of the independent variable–baseline HRQoL (measured by the Short-Form-6D)–controlling for total exposure time and experiment group (i.e., exercise or usual care) for the total sample. For the usual care group alone, the model controlled for total exposure time. Results: For the total sample, the rate of subsequent total falls was significantly predicted by baseline HRQoL (IRR = 0.044; 95% CI [0.005–0.037]; p =.004). For the usual care group, findings were confirmed with wider confidence intervals and the rate of prospective total falls was significantly predicted by baseline HRQoL (IRR = 0.025; 95% CI [0.001–0.909]; p =.044). Conclusion: These findings suggest the ShortForm-6D should be considered as part of falls prevention screening strategies within a Falls Prevention Clinic setting. Trial Registrations ClinicalTrials.gov Protocol Registration System. Identifier: NCT01029171; URL: https://clinicaltrials.gov/ct2/show/NCT01029171. Identifier: NCT00323596; URL: https://clinicaltrials.gov/ct2/show/NCT00323596.
AB - Purpose: Among older adults, health-related quality of life (HRQoL) and falls are associated. Generic patient-reported outcomes measures (PROMs) assess individual’s HRQoL. The role for PROMs, a potential tool for predicting subsequent falls, remains under-explored. Our primary aim was to determine whether a baseline PROMs assessment of HRQoL may be a useful tool for predicting future falls. Methods: A secondary analysis of a 12-month randomized clinical trial (RCT) of a home-based exercise program among 344 adults (67% female), aged ≥ 70 years, with ≥ 1 falls in the prior year who were randomized (1:1) to either a home-based exercise program (n = 172) or usual care (n = 172). A negative binomial regression model with total falls count as the dependent variable evaluated the main effect of the independent variable–baseline HRQoL (measured by the Short-Form-6D)–controlling for total exposure time and experiment group (i.e., exercise or usual care) for the total sample. For the usual care group alone, the model controlled for total exposure time. Results: For the total sample, the rate of subsequent total falls was significantly predicted by baseline HRQoL (IRR = 0.044; 95% CI [0.005–0.037]; p =.004). For the usual care group, findings were confirmed with wider confidence intervals and the rate of prospective total falls was significantly predicted by baseline HRQoL (IRR = 0.025; 95% CI [0.001–0.909]; p =.044). Conclusion: These findings suggest the ShortForm-6D should be considered as part of falls prevention screening strategies within a Falls Prevention Clinic setting. Trial Registrations ClinicalTrials.gov Protocol Registration System. Identifier: NCT01029171; URL: https://clinicaltrials.gov/ct2/show/NCT01029171. Identifier: NCT00323596; URL: https://clinicaltrials.gov/ct2/show/NCT00323596.
KW - Falls
KW - Health-related quality of life
KW - Older adults
KW - Patient-reported outcomes measure
KW - SF-6D
UR - http://www.scopus.com/inward/record.url?scp=85133597481&partnerID=8YFLogxK
U2 - 10.1007/s11136-022-03175-2
DO - 10.1007/s11136-022-03175-2
M3 - Journal article
C2 - 35798988
AN - SCOPUS:85133597481
SN - 0962-9343
VL - 31
SP - 3211
EP - 3220
JO - Quality of Life Research
JF - Quality of Life Research
IS - 11
ER -