Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome

Qian Wei, Xia Hao, Benson Wui Man Lau, Shaoxia Wang, Yue Li (Corresponding Author)

Research output: Journal article publicationReview articleAcademic researchpeer-review

3 Citations (Scopus)

Abstract

It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharmacological effects and is beneficial in enhancing osteogenic differentiation and cardiovascular disease. Baicalin’s profound metabolic impact on various stem cell populations and their fate specification could improve the efficiency of stem cell therapy for climacteric syndrome. However, Baicalin-mediated processes are complex and many of the underlying mechanisms are not fully fathomed yet. This review aims to shed light on the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and provide a good cell source for stem cell therapy to broaden the therapeutic landscape for climacteric syndrome patients.

Original languageEnglish
Article number986436
JournalFrontiers in Pharmacology
Volume13
DOIs
Publication statusPublished - 2 Nov 2022

Keywords

  • baicalin
  • climacteric syndrome
  • differentiation
  • proliferation
  • stem cell

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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