Bacterial Transcription Inhibitor of RNA Polymerase Holoenzyme Formation by Structure-Based Drug Design: From in Silico Screening to Validation

Keyphrases

• Transcription Inhibitors 100%
• In Silico Screening 100%
• Bacterial Gene Expression 100%
• Structure-based Drug Design 100%
• RNA Polymerase Holoenzyme 100%
• Bacterial RNA Polymerase 66%
• Microscopy 33%
• Bacillus Subtilis (B. subtilis) 33%
• Growth Inhibition 33%
• Binding Site 33%
• Cell Activity 33%
• Living Cells 33%
• In Vitro Assay 33%
• RNA Polymerase II (RNAPII) 33%
• Excellent Activity 33%
• Publicly Available 33%
• Inhibitor Development 33%
• Virtual Screening 33%
• Pharmacophore Model 33%
• Discovery Process 33%
• Target Specificity 33%
• Holoenzyme 33%
• Biochemical Verification 33%
• Equivalent Structure 33%
• Gram-positive Organisms 33%
• Specific Affinity 33%
• Natural Extracts 33%
• RNA Polymerase Activity 33%
• Targeted Inhibitors 33%
• Antibacterial Activity 33%

Medicine and Dentistry

• In Silico 100%
• RNA Polymerase 100%
• Holoenzyme 100%
• Bacterial RNA 50%
• In Vitro 25%
• Antiinfective Agent 25%
• Pharmacophore 25%
• Growth Inhibition 25%
• Cell Activity 25%
• Virtual Screening 25%
• Bacillus subtilis 25%
• Antibacterial Activity 25%
• Binding Site 25%
• Gram-Positive Bacteria 25%
• RNA Polymerase II 25%

Biochemistry, Genetics and Molecular Biology

• Bacterial Transcription 100%
• RNA Polymerase 100%
• Drug Development 100%
• Transcription 25%
• Antibacterial Activity 25%
• Extract 25%
• Pharmacophore 25%
• Cell Activity 25%
• Binding Site 25%
• Bacilli 25%
• Gram Positive Bacterium 25%
• Growth Inhibition 25%
• RNA Polymerase II 25%