Autonomic dysfunction in ischemic stroke with carotid stenosis

L. Xiong, H.W. Leung, Xiangyan Chen, J.H. Han, W.H. Leung, O.Y. Soo, Y.L. Lau, K.S. Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

Objectives- Impaired autonomic function is common in acute ischemic stroke. Previous limited studies have suggested that atherosclerosis may affect the distensibility of the carotid sinus and then impair the cardiovascular autonomic function. This study sought to investigate cardiovascular autonomic function in patients with ischemic stroke with carotid stenosis. Methods- Eighty-five patients with ischemic stroke (58 ones without carotid stenosis and 27 ones with carotid stenosis, average 6months after stroke onset) and 37 elderly controls were recruited. All performed Ewing's battery autonomic function tests. Results- From Ewing's battery of autonomic function tests, atypical, definite, or severe autonomic dysfunction was identified in 69.0% patients without carotid stenosis and 88.9% with carotid stenosis, with significant difference between the two groups, and the prevalence of autonomic dysfunction in both groups was higher than that in controls (21.6%). Patients with carotid stenosis showed impairment of all parasympathetic tests (all P<0.05) and one of the sympathetic tests [Mean fall in systolic blood pressure (BP) on standing: P=0.051], and those without carotid stenosis only showed impairment in two parasympathetic tests (Valsalva ratio: P=0.014; heart rate response to deep breathing: P<0.001) in comparison with controls. Patients with carotid stenosis had significantly more impairment than those without carotid stenosis in some autonomic parameters (Valsalva ratio: P<0.05; mean fall in systolic BP on standing: P<0.05). Conclusions- Cardiovascular autonomic function is impaired in patients with ischemic stroke, but patients with carotid stenosis show more severely impaired parasympathetic and sympathetic functions. © 2011 John Wiley & Sons A/S.
Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalActa Neurologica Scandinavica
Volume126
Issue number2
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Keywords

  • Autonomic dysfunction
  • Carotid stenosis
  • Ischemic stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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