Automated assembly of biological cells in a 3D scaffold via dielectrophoresis manipulation

Zhijie Huan, Kar Hang Chu, Jie Yang, Dong Sun

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Patterning and assembly of biological cells in a 3D structure represents an important process in artificial tissue engineering. This paper presents the design of a multi-layer electrode scaffold used to assemble biological cells into a 3D pattern. Through suppling voltage to the multi-layer scaffold, three-dimensional electric fields can be established to manipulate cells towards the scaffold via dielectrophoresis (DEP). To fabricate such a 3D scaffold, we utilized the laser cutting technology to cut stainless steel into a precision structure with integrated micro-tips. Layers of the structure were then stacked together forming the 3D scaffold. Experiments were conducted and the scaffold was able to generate the DEP force and assemble biological cells at the desired positions with required patterning.
Original languageEnglish
Title of host publication2014 IEEE International Conference on Information and Automation, ICIA 2014
PublisherIEEE
Pages345-349
Number of pages5
ISBN (Electronic)9781479941001
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes
Event2014 IEEE International Conference on Information and Automation, ICIA 2014 - Hailar, Hulunbuir, China
Duration: 28 Jul 201430 Jul 2014

Conference

Conference2014 IEEE International Conference on Information and Automation, ICIA 2014
CountryChina
CityHailar, Hulunbuir
Period28/07/1430/07/14

ASJC Scopus subject areas

  • Modelling and Simulation

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