Atherosclerosis Treatment with Stimuli-Responsive Nanoagents: Recent Advances and Future Perspectives

Ali Maruf, Yi Wang, Tieyin Yin, Junli Huang, Nan Wang, Colm Durkan, Youhua Tan, Wei Wu, Guixue Wang

Research output: Journal article publicationReview articleAcademic researchpeer-review

15 Citations (Scopus)

Abstract

Atherosclerosis is the root of approximately one-third of global mortalities. Nanotechnology exhibits splendid prospects to combat atherosclerosis at the molecular level by engineering smart nanoagents with versatile functionalizations. Significant advances in nanoengineering enable nanoagents to autonomously navigate in the bloodstream, escape from biological barriers, and assemble with their nanocohort at the targeted lesion. The assembly of nanoagents with endogenous and exogenous stimuli breaks down their shells, facilitates intracellular delivery, releases their cargo to kill the corrupt cells, and gives imaging reports. All these improvements pave the way toward personalized medicine for atherosclerosis. This review systematically summarizes the recent advances in stimuli-responsive nanoagents for atherosclerosis management and its progress in clinical trials.

Original languageEnglish
Article number1900036
JournalAdvanced healthcare materials
Volume8
Issue number11
DOIs
Publication statusPublished - 6 Jun 2019

Keywords

  • atherosclerosis
  • nanoagents
  • stimuli-responsiveness

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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