An easily accessible chiral lr/H8-binapo catalyst exhibits unprecedented reactivity and excellent enantioselectivity in the hydrogenation of quinoxalines at a high ratio of substrate to catalyst (from 100 to 20000). This new method provides a practical synthetic approach to give optically active chiral tetrahydroquinoxaline derivatives (see scheme; cod = l, 5-cyclooctadiene).
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 16 Nov 2009|
- Asymmetric catalysis
- Diphosphinite ligands
ASJC Scopus subject areas