Associations between blood and urinary manganese with metabolic syndrome and its components: Cross-sectional analysis of National Health and Nutrition Examination Survey 2011–2016

Kenneth Lo, Jing Li Yang, Chao Lei Chen, Lin Liu, Yu Qing Huang, Ying Qing Feng, Ai Min Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

3 Citations (Scopus)


Manganese (Mn) may improve cardiometabolic health with its anti-oxidative ability. However, epidemiological evidence on the overall and sex-specific relationship between Mn exposure and metabolic syndrome (MetS) has been inconclusive. We evaluated the associations of urinary (n = 1713) and blood (n = 3335) Mn levels with the prevalence of MetS, its components (elevated waist circumference, impaired glucose metabolism, elevated blood pressure and dyslipidemia) and sex-dependent heterogeneities among participants in the United States National Health and Nutrition Examination Survey 2011–2016. After adjusting for multiple covariates and the levels of other metals (Arsenic, Barium, Cadmium, Mercury, Molybdenum, Tin and Uranium), urinary Mn at the third quartile associated with a lower odd of MetS (odds ratio [OR] = 0.55, 95% confidence interval [C.I.] = 0.32–0.97), elevated waist circumference (OR = 0.56, 95% C.I. = 0.36–0.86) and elevated fasting plasma glucose (OR = 0.46, 95% C.I. = 0.27–0.76) among overall participants, and lower odds of MetS (OR = 0.40, 95% C.I. = 0.16–0.99), elevated waist circumference (OR = 0.39, 95% C.I. = 0.19–0.81) and elevated fasting plasma glucose (OR = 0.44, 95% C.I. = 0.22–0.90) among men. The U-shaped dose-response relationship between urinary Mn and MetS (P non-linear = 0.008) was observed among all participants. We did not observe the significant associations of blood Mn with the prevalence of MetS. Compared with other metals, urinary Mn played a less important role in development of MetS (posterior inclusion probabilities [PIP] = 0.49 for Mn versus 0.54 to 0.91 for other metals), but the contribution of blood Mn (PIP = 0.59 versus 0.60 to 0.61) was similar to other blood metals (Cadmium, Lead, Mercury and Selenium). These findings have provided new evidence of the potential roles of Mn in cardiometabolic health, and the needs to explore how Mn interacts with multiple metals in sex-specific manner.

Original languageEnglish
Article number146527
JournalScience of the Total Environment
Publication statusPublished - 1 Aug 2021


  • Dyslipidemias
  • Hypertension
  • Manganese
  • Metabolic syndrome
  • Metals
  • Obesity

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

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