Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population

Huan Chen, Junquan Xu, Yuxi Zhou, Yong Gao, Guoqing Wang, Jiguang Xia, Michael S.Y. Huen, Wai Ting Siok, Yuyang Jiang, Li Hai Tan (Corresponding Author), Yimin Sun (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

Background: Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of, and with stuttering, we investigated these genes with dyslexia through association analysis. Results: The study was carried out in an unrelated Chinese cohort with 502 dyslexic individuals and 522 healthy controls. In all, 21 Tag SNPs covering, and were subjected to genotyping. Association analysis was performed on all SNPs. Significant association of rs17031962 in and rs882294 in with developmental dyslexia was identified after FDR correction for multiple comparisons. Conclusion: Our results revealed that the stuttering risk genes and might also associate with developmental dyslexia in the Chinese population.

Original languageEnglish
Article number7
JournalBMC Genetics
Volume16
Issue number1
DOIs
Publication statusPublished - 3 Feb 2015
Externally publishedYes

Keywords

  • Developmental dyslexia
  • GNPTAB
  • GNPTG
  • NAGPA
  • SNPs

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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