Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population

Yimin Sun (Corresponding Author), Yong Gao (Corresponding Author), Yuxi Zhou, Huan Chen, Guoqing Wang, Junquan Xu, Jiguang Xia, Michael S.Y. Huen, Wai Ting Siok, Yuyang Jiang, Li Hai Tan (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

20 Citations (Scopus)

Abstract

Developmental dyslexia (DD) is characterized by difficulties in reading and spelling independent of intelligence, educational backgrounds and neurological injuries. Increasing evidences supported DD as a complex genetic disorder and identified four DD candidate genes namely DYX1C1, DCDC2, KIAA0319 and ROBO1. As such, DCDC2 and KIAA0319 are located in DYX2, one of the most studied DD susceptibility loci. However, association of these two genes with DD was inconclusive across different populations. Given the linguistic and genetic differences between Chinese and other populations, it is worthwhile to investigate association of DCDC2 and KIAA0319 with Chinese dyslexic children. Here, we selected 60 tag SNPs covering DCDC2 and KIAA0319 followed by high density genotyping in a large unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. Several SNPs (Pmin=0.0192) of DCDC2 and KIAA0319 as well as a four-maker haplotype (Padjusted=0.0289, Odds Ratio (OR) =1.3400) of KIAA0319 showed nominal association with DD. However, none of these results survived Bonferroni correction for multiple comparisons. Thus, the association of DCDC2 and KIAA0319 with DD in Chinese population should be further validated and their contribution to DD etiology and pathology should be interpreted with caution.

Original languageEnglish
Pages (from-to)627-634
Number of pages8
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume165
Issue number8
Early online date17 Sept 2014
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Keywords

  • Association study
  • DCDC2
  • Developmental dyslexia
  • KIAA0319
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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