Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

You Qiang Song, Kenneth M.C. Cheung, Daniel W.H. Ho, Sandy C.S. Poon, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yuichiro Hirose, Mauro Alini, Sibylle Grad, Anita F.Y. Yee, John C C.Y. Leong, Keith D.K. Luk, Shea Ping Yip, Jaro Karppinen, Kathryn S.E. Cheah, Pak Sham, Shiro Ikegawa, Danny Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

99 Citations (Scopus)

Abstract

Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
Original languageEnglish
Pages (from-to)744-747
Number of pages4
JournalAmerican Journal of Human Genetics
Volume82
Issue number3
DOIs
Publication statusPublished - 3 Mar 2008

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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