Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

You Qiang Song; Kenneth M.C. Cheung; Daniel W.H. Ho; Sandy C.S. Poon; Kazuhiro Chiba; Yoshiharu Kawaguchi; Yuichiro Hirose; Mauro Alini; Sibylle Grad; Anita F.Y. Yee; John C C.Y. Leong; Keith D.K. Luk; Shea Ping Yip; Jaro Karppinen; Kathryn S.E. Cheah; Pak Sham; Shiro Ikegawa; Danny Chan

doi:10.1016/j.ajhg.2007.12.017

Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

You Qiang Song, Kenneth M.C. Cheung, Daniel W.H. Ho, Sandy C.S. Poon, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yuichiro Hirose, Mauro Alini, Sibylle Grad, Anita F.Y. Yee, John C C.Y. Leong, Keith D.K. Luk, Shea Ping Yip, Jaro Karppinen, Kathryn S.E. Cheah, Pak Sham, Shiro Ikegawa, Danny Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

110 Citations (Scopus)

Abstract

Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

Original language	English
Pages (from-to)	744-747
Number of pages	4
Journal	American Journal of Human Genetics
Volume	82
Issue number	3
DOIs	https://doi.org/10.1016/j.ajhg.2007.12.017
Publication status	Published - 3 Mar 2008

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1016/j.ajhg.2007.12.017

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Song, Y. Q., Cheung, K. M. C., Ho, D. W. H., Poon, S. C. S., Chiba, K., Kawaguchi, Y., Hirose, Y., Alini, M., Grad, S., Yee, A. F. Y., Leong, JC. C. Y., Luk, K. D. K., Yip, S. P., Karppinen, J., Cheah, K. S. E., Sham, P., Ikegawa, S., & Chan, D. (2008). Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians. American Journal of Human Genetics, 82(3), 744-747. https://doi.org/10.1016/j.ajhg.2007.12.017

@article{6fd38b6525744624a42f79991d811bea,

title = "Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians",

abstract = "Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.",

author = "Song, {You Qiang} and Cheung, {Kenneth M.C.} and Ho, {Daniel W.H.} and Poon, {Sandy C.S.} and Kazuhiro Chiba and Yoshiharu Kawaguchi and Yuichiro Hirose and Mauro Alini and Sibylle Grad and Yee, {Anita F.Y.} and Leong, {John C C.Y.} and Luk, {Keith D.K.} and Yip, {Shea Ping} and Jaro Karppinen and Cheah, {Kathryn S.E.} and Pak Sham and Shiro Ikegawa and Danny Chan",

year = "2008",

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doi = "10.1016/j.ajhg.2007.12.017",

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Song, YQ, Cheung, KMC, Ho, DWH, Poon, SCS, Chiba, K, Kawaguchi, Y, Hirose, Y, Alini, M, Grad, S, Yee, AFY, Leong, JCCY, Luk, KDK, Yip, SP, Karppinen, J, Cheah, KSE, Sham, P, Ikegawa, S & Chan, D 2008, 'Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians', American Journal of Human Genetics, vol. 82, no. 3, pp. 744-747. https://doi.org/10.1016/j.ajhg.2007.12.017

TY - JOUR

T1 - Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

AU - Song, You Qiang

AU - Cheung, Kenneth M.C.

AU - Ho, Daniel W.H.

AU - Poon, Sandy C.S.

AU - Chiba, Kazuhiro

AU - Kawaguchi, Yoshiharu

AU - Hirose, Yuichiro

AU - Alini, Mauro

AU - Grad, Sibylle

AU - Yee, Anita F.Y.

AU - Leong, John C C.Y.

AU - Luk, Keith D.K.

AU - Yip, Shea Ping

AU - Karppinen, Jaro

AU - Cheah, Kathryn S.E.

AU - Sham, Pak

AU - Ikegawa, Shiro

AU - Chan, Danny

PY - 2008/3/3

Y1 - 2008/3/3

N2 - Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

AB - Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

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DO - 10.1016/j.ajhg.2007.12.017

M3 - Journal article

C2 - 18304494

SN - 0002-9297

VL - 82

SP - 744

EP - 747

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

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