Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population

Guoqing Wang; Yuxi Zhou; Yong Gao; Huan Chen; Jiguang Xia; Junquan Xu; Michael S.Y. Huen; Wai Ting Siok; Yuyang Jiang; Li Hai Tan; Yimin Sun

doi:10.1016/j.jneuroling.2014.06.005

Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population

Guoqing Wang, Yuxi Zhou, Yong Gao, Huan Chen, Jiguang Xia, Junquan Xu, Michael S.Y. Huen, Wai Ting Siok, Yuyang Jiang, Li Hai Tan (Corresponding Author), Yimin Sun (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

6 Citations (Scopus)

Abstract

Developmental dyslexia (DD) and specific language impairment (SLI) are distinct language disorders. Their phenotypic overlap and co-morbidity are frequently reported. In addition, numerous evidences indicate that genetic factors play an important role in DD and SLI. Therefore, it is worthwhile to identify possible genetic linkage shared by these two disorders. Here, we selected 178 Tag SNPs from two SLI candidate genes (CMIP and ATP2C2) and performed high density genotyping in a large unrelated Chinese DD cohort with 502 dyslexic cases and 522 healthy controls. Although some SNPs showed significant association (P_min=0.0016) with DD through case-control based association analysis, none of them survived Bonferroni correction for multiple comparisons. Thus, the association of SLI candidate genes CMIP and ATP2C2 with DD in Chinese population should be further validated and their contribution to DD should be interpreted with caution.

Original language	English
Pages (from-to)	163-171
Number of pages	9
Journal	Journal of Neurolinguistics
Volume	33
Early online date	22 Jul 2014
DOIs	https://doi.org/10.1016/j.jneuroling.2014.06.005
Publication status	Published - 1 Feb 2015
Externally published	Yes

Keywords

ATP2C2
CMIP
Developmental dyslexia
Single nucleotide polymorphism
Specific language impairment

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Arts and Humanities (miscellaneous)
Linguistics and Language
Cognitive Neuroscience

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10.1016/j.jneuroling.2014.06.005

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title = "Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population",

abstract = "Developmental dyslexia (DD) and specific language impairment (SLI) are distinct language disorders. Their phenotypic overlap and co-morbidity are frequently reported. In addition, numerous evidences indicate that genetic factors play an important role in DD and SLI. Therefore, it is worthwhile to identify possible genetic linkage shared by these two disorders. Here, we selected 178 Tag SNPs from two SLI candidate genes (CMIP and ATP2C2) and performed high density genotyping in a large unrelated Chinese DD cohort with 502 dyslexic cases and 522 healthy controls. Although some SNPs showed significant association (Pmin=0.0016) with DD through case-control based association analysis, none of them survived Bonferroni correction for multiple comparisons. Thus, the association of SLI candidate genes CMIP and ATP2C2 with DD in Chinese population should be further validated and their contribution to DD should be interpreted with caution.",

keywords = "ATP2C2, CMIP, Developmental dyslexia, Single nucleotide polymorphism, Specific language impairment",

author = "Guoqing Wang and Yuxi Zhou and Yong Gao and Huan Chen and Jiguang Xia and Junquan Xu and Huen, {Michael S.Y.} and Siok, {Wai Ting} and Yuyang Jiang and Tan, {Li Hai} and Yimin Sun",

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doi = "10.1016/j.jneuroling.2014.06.005",

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TY - JOUR

T1 - Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population

AU - Wang, Guoqing

AU - Zhou, Yuxi

AU - Gao, Yong

AU - Chen, Huan

AU - Xia, Jiguang

AU - Xu, Junquan

AU - Huen, Michael S.Y.

AU - Siok, Wai Ting

AU - Jiang, Yuyang

AU - Tan, Li Hai

AU - Sun, Yimin

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Developmental dyslexia (DD) and specific language impairment (SLI) are distinct language disorders. Their phenotypic overlap and co-morbidity are frequently reported. In addition, numerous evidences indicate that genetic factors play an important role in DD and SLI. Therefore, it is worthwhile to identify possible genetic linkage shared by these two disorders. Here, we selected 178 Tag SNPs from two SLI candidate genes (CMIP and ATP2C2) and performed high density genotyping in a large unrelated Chinese DD cohort with 502 dyslexic cases and 522 healthy controls. Although some SNPs showed significant association (Pmin=0.0016) with DD through case-control based association analysis, none of them survived Bonferroni correction for multiple comparisons. Thus, the association of SLI candidate genes CMIP and ATP2C2 with DD in Chinese population should be further validated and their contribution to DD should be interpreted with caution.

AB - Developmental dyslexia (DD) and specific language impairment (SLI) are distinct language disorders. Their phenotypic overlap and co-morbidity are frequently reported. In addition, numerous evidences indicate that genetic factors play an important role in DD and SLI. Therefore, it is worthwhile to identify possible genetic linkage shared by these two disorders. Here, we selected 178 Tag SNPs from two SLI candidate genes (CMIP and ATP2C2) and performed high density genotyping in a large unrelated Chinese DD cohort with 502 dyslexic cases and 522 healthy controls. Although some SNPs showed significant association (Pmin=0.0016) with DD through case-control based association analysis, none of them survived Bonferroni correction for multiple comparisons. Thus, the association of SLI candidate genes CMIP and ATP2C2 with DD in Chinese population should be further validated and their contribution to DD should be interpreted with caution.

KW - ATP2C2

KW - CMIP

KW - Developmental dyslexia

KW - Single nucleotide polymorphism

KW - Specific language impairment

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U2 - 10.1016/j.jneuroling.2014.06.005

DO - 10.1016/j.jneuroling.2014.06.005

M3 - Journal article

AN - SCOPUS:84918519706

SN - 0911-6044

VL - 33

SP - 163

EP - 171

JO - Journal of Neurolinguistics

JF - Journal of Neurolinguistics

ER -

Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population

Abstract

Keywords

ASJC Scopus subject areas

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