Association of CFH polymorphism with susceptibility toA multi-center study sepsis caused by Pseudomonas aeruginosa in Chinese Han populations: A multi-center study

Jia Li, Ding Long, Sisi Wu, Xiaoling Wu, Bohua Wei, Dan Chen, Yiming Shao, Hongliang Wang, Lili Cui, Xiangyan Chen, Li Yu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Complement factor H (CFH) serves as a major down-regulator in the complement system, often utilized by bacterial pathogens to evade complement attack. Yet, little is currently known about the genetic correlation of CFH polymorphisms with sepsis due to various microbial infections. A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations. Our findings indicated that the frequency of rs3753394 CT/TT genotype in the septic patients with P. aeruginosa was significantly higher than that in the control individuals (P = 0.033, OR = 2.668, 95%CI = 1.072–6.334). The rs3753394 T allele frequency in the P. aeruginosa-infected patients was significantly increased, compared to that in the healthy controls (P = 0.014, OR = 1.68, 95%CI = 1.118–2.538). Moreover, these significant differences of rs3753394 genotype and allele frequencies remained after multiple testing corrections [P (corr.) = 0.033 for genotype; P (corr.) = 0.033 for allele]. The current study highlighted the significance of CFH polymorphism rs3753394 as a potential biomarker for targeting P. aeruginosa infection in critically ill patients.

Original languageEnglish
Article number144127
JournalGene
Volume722
Early online date13 Sep 2019
DOIs
Publication statusPublished - 5 Jan 2020

Keywords

  • CFH
  • Pseudomonas aeruginosa
  • Sepsis
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics

Cite this