Association between initial mfERG responses and myopic progression in children with and without prescription of Breath-O Correct orthokeratology lenses

Kai Yip Choi, Tsz King Wong, Chuen Lam, Ho Lung Henry Chan

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Purpose: To investigate the relationship between the initial retinal electrophysiological response and axial elongation (AE) in children with and without prescription of Breath-O Correct orthokeratology (OK) lenses.

Methods: Eighty-five subjects aged 9 to 12 years with spherical equivalent refraction (SER) between -1.00D and -4.00D were recruited and randomly assigned into OK (n=49) or spectacle control (n=36) groups. Breath-O Correct lenses were prescribed in OK group with routinely scheduled aftercare. Retinal electrophysiological responses were measured by global flash multifocal electroretinogram (mfERG) in 49% contrast at baseline before any intervention. Responses from the 61 hexagons were averaged into 5 concentric rings to investigate the localized responses at different retinal eccentricities. Axial length measurements were performed at baseline and one-year to monitor refractive changes. Spearman’s correlation with Bonferroni correction was used to assess the relationship between mfERG and AE.

Results: Seventy-one subjects completed this one-year study (Control: 29, OK: 42). The baseline SER for control and OK group were -2.49D and -2.97D (t-test, p>0.05), respectively. The mean AE in OK group was significantly lower than the control group (Control: 0.35±0.2mm, OK: 0.14±0.17mm, p<0.01). In OK group, no significant correlation was noted between AE and the initial mfERG responses (p>0.05). In contrast, for the control group, the AE was negatively correlated with baseline Ring 1 induced component amplitude (p=-0.484, p<0.01, representing the central inner retinal response) and Ring 3 direct component amplitude (ρ=-0.488, p<0.01, representing the para-central outer retinal response), respectively.

Conclusions: Without OK intervention, weaker retinal response was associated with faster myopic progression. However, this risk factor did not predispose faster AE under the effect of Breath-O Correct OK intervention. It indicates that the OK intervention is suitable for children with different myopia progression rates.
Original languageEnglish
Title of host publicationInvestigative Ophthalmology and Visual Science
Pages602
Volume62
ISBN (Electronic)1552-5783
Publication statusPublished - 1 Jun 2021
EventAssociation for Research in Vision and Ophthalmology (ARVO) Annual Meeting -
Duration: 1 May 20217 May 2021

Conference

ConferenceAssociation for Research in Vision and Ophthalmology (ARVO) Annual Meeting
Period1/05/217/05/21

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