Association between initial mfERG responses and myopic progression in children with and without prescription of Breath-O Correct orthokeratology lenses

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Purpose: To investigate the relationship between the initial retinal electrophysiological response and axial elongation (AE) in children with and without prescription of Breath-O Correct orthokeratology (OK) lenses.

Methods: Eighty-five subjects aged 9 to 12 years with spherical equivalent refraction (SER) between -1.00D and -4.00D were recruited and randomly assigned into OK (n=49) or spectacle control (n=36) groups. Breath-O Correct lenses were prescribed in OK group with routinely scheduled aftercare. Retinal electrophysiological responses were measured by global flash multifocal electroretinogram (mfERG) in 49% contrast at baseline before any intervention. Responses from the 61 hexagons were averaged into 5 concentric rings to investigate the localized responses at different retinal eccentricities. Axial length measurements were performed at baseline and one-year to monitor refractive changes. Spearman’s correlation with Bonferroni correction was used to assess the relationship between mfERG and AE.

Results: Seventy-one subjects completed this one-year study (Control: 29, OK: 42). The baseline SER for control and OK group were -2.49D and -2.97D (t-test, p>0.05), respectively. The mean AE in OK group was significantly lower than the control group (Control: 0.35±0.2mm, OK: 0.14±0.17mm, p<0.01). In OK group, no significant correlation was noted between AE and the initial mfERG responses (p>0.05). In contrast, for the control group, the AE was negatively correlated with baseline Ring 1 induced component amplitude (p=-0.484, p<0.01, representing the central inner retinal response) and Ring 3 direct component amplitude (ρ=-0.488, p<0.01, representing the para-central outer retinal response), respectively.

Conclusions: Without OK intervention, weaker retinal response was associated with faster myopic progression. However, this risk factor did not predispose faster AE under the effect of Breath-O Correct OK intervention. It indicates that the OK intervention is suitable for children with different myopia progression rates.
Original languageEnglish
Title of host publicationInvestigative Ophthalmology and Visual Science
ISBN (Electronic)1552-5783
Publication statusPublished - 1 Jun 2021
EventAssociation for Research in Vision and Ophthalmology (ARVO) Annual Meeting -
Duration: 1 May 20217 May 2021


ConferenceAssociation for Research in Vision and Ophthalmology (ARVO) Annual Meeting

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