Assessor- and participant-blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke

Zhang Jin Zhang, Hong Zhao, Gui Xing Jin, Sui Cheung Man, Yi Si Wang, Ying Wang, Hai Rong Wang, Meng Han Li, Lo Lo Yam, Zong Shi Qin, Kim Kam Teresa Yu, Jing Wu, Fung Leung Bacon Ng, Tat Chi Eric Ziea, Pei Jing Rong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

Aim: Acupuncture has benefits in the rehabilitation of neuropsychiatric sequelae of stroke. This study was aimed to evaluate the effectiveness of dense cranial electroacupuncture stimulation plus body acupuncture (DCEAS+BA) in treating poststroke depression (PSD), functional disability, and cognitive deterioration. Methods: In this assessor- and participant-blinded, randomized controlled trial, 91 stroke patients who initially had PSD were randomly assigned to either DCEAS+BA (n = 45) or minimum acupuncture stimulation as controls (n = 46) for three sessions per week over 8 consecutive weeks. The primary outcome was baseline-to-end-point change in score of the 17-item Hamilton Depression Rating Scale. Secondary outcomes included the Montgomery–Åsberg Depression Rating Scale for depressive symptoms, the Barthel Index for functional disability, and the Montreal Cognitive Assessment for cognitive function. Results: DCEAS+BA-treated patients showed strikingly greater end-point reduction than MAS-treated patients in scores of the three symptom domains. The clinical response rate, defined as an at least 50% baseline-to-end-point reduction in 17-item Hamilton Depression Rating Scale score, was markedly higher in the DCEAS+BA-treated group than that of controls (40.0% vs 17.4%, P = 0.031). Incidence of adverse events was not different in the two groups. Subgroup analysis revealed that DCEAS+BA with electrical stimulation on forehead acupoints was more apparent in reducing Barthel-Index-measured disability than that without electrical stimulation. Conclusion: DCEAS+BA, particularly with electrical stimulation on forehead acupoints, reduces PSD, functional disability, and cognitive deterioration of stroke patients. It can serve as an effective rehabilitation therapy for neuropsychiatric sequelae of stroke.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalPsychiatry and Clinical Neurosciences
Volume74
Issue number3
DOIs
Publication statusPublished - 1 Mar 2020
Externally publishedYes

Keywords

  • acupuncture
  • cognitive impairment
  • dense cranial electroacupuncture stimulation (DCEAS)
  • functional disability
  • poststroke depression

ASJC Scopus subject areas

  • General Neuroscience
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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