TY - JOUR
T1 - Assessment measures for chemotherapy-induced peripheral neuropathy among pediatric oncology patients
T2 - an updated systematic review
AU - Mao, Ting
AU - Yorke, Janelle
AU - Shi, Yan
AU - Shen, Nanping
AU - Wang, Haixia
AU - Wong, Frances Kam Yuet
AU - Lam, Katherine Ka Wai
AU - Tang, Lai Ngo
AU - Liu, Qi
AU - Abu-Odah, Hammoda
AU - Belay, Getaneh Mulualem
AU - Yang, Funa
AU - Wang, Li
AU - Cheng, Frankie Wai Tsoi
AU - Zhang, Xiaoju
AU - Ho, Ka Yan
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/6
Y1 - 2025/6
N2 - Objective: To update the systematic review of assessment tools on chemotherapy-induced peripheral neuropathy (CIPN) for pediatric oncology patients based on the evidence available after the published review in 2020. Data sources: Seven English-language databases (PubMed, CINAHL, PsycINFO, EMBASE, the Cochrane Central Register of Controlled Trials, Scopus and Web of Science) were searched for studies published from Nov 9, 2018, to May 20, 2024. Study selection: Studies that contained subjects who had a cancer diagnosis and were aged under 18 years and discussed the development of a tool to measure CIPN or assessed all test items and response categories for CIPN were included. Data extraction and synthesis: Data were screened and extracted independently using predesigned tables. The quality of each study was assessed based on Joanna Briggs Institute’s critical appraisal tools for analytical cross-sectional studies and case control studies. The quality of identified instruments for CIPN was evaluated by the modified version of Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Results: A total of 5 studies (with 633 patients) were included in the systematic review. Only one study was rated as high quality. We newly identified two patient-reported outcome measures (PROMs), one objective assessment and a pain scale, and three new studies about the previous identified CIPN assessment measures. Conclusions and relevance: Based on the current evidence, the pediatric-modified Total Neuropathy Score (ped-mTNS) and the Total Neuropathy Score-Pediatric Vincristine (TNS-PV) are still the two most appropriate tools for healthcare professionals to use in clinical settings. Our results also addressed the gap in existing literature by showing two newly PROMs for CIPN in pediatric oncology patients with acceptable quality. The combination of physician-based assessment tools and PROMs are recommended to evaluate the patients’ CIPN-related symptoms.
AB - Objective: To update the systematic review of assessment tools on chemotherapy-induced peripheral neuropathy (CIPN) for pediatric oncology patients based on the evidence available after the published review in 2020. Data sources: Seven English-language databases (PubMed, CINAHL, PsycINFO, EMBASE, the Cochrane Central Register of Controlled Trials, Scopus and Web of Science) were searched for studies published from Nov 9, 2018, to May 20, 2024. Study selection: Studies that contained subjects who had a cancer diagnosis and were aged under 18 years and discussed the development of a tool to measure CIPN or assessed all test items and response categories for CIPN were included. Data extraction and synthesis: Data were screened and extracted independently using predesigned tables. The quality of each study was assessed based on Joanna Briggs Institute’s critical appraisal tools for analytical cross-sectional studies and case control studies. The quality of identified instruments for CIPN was evaluated by the modified version of Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Results: A total of 5 studies (with 633 patients) were included in the systematic review. Only one study was rated as high quality. We newly identified two patient-reported outcome measures (PROMs), one objective assessment and a pain scale, and three new studies about the previous identified CIPN assessment measures. Conclusions and relevance: Based on the current evidence, the pediatric-modified Total Neuropathy Score (ped-mTNS) and the Total Neuropathy Score-Pediatric Vincristine (TNS-PV) are still the two most appropriate tools for healthcare professionals to use in clinical settings. Our results also addressed the gap in existing literature by showing two newly PROMs for CIPN in pediatric oncology patients with acceptable quality. The combination of physician-based assessment tools and PROMs are recommended to evaluate the patients’ CIPN-related symptoms.
KW - Assessment measure
KW - Chemotherapy-induced peripheral neuropathy
KW - Pediatric oncology
KW - Systematic review
UR - https://www.scopus.com/pages/publications/105006910523
U2 - 10.1007/s00520-025-09515-5
DO - 10.1007/s00520-025-09515-5
M3 - Review article
C2 - 40442349
AN - SCOPUS:105006910523
SN - 0941-4355
VL - 33
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 6
M1 - 514
ER -
