Application of TPMS structure in bone regeneration

Zhifei Dong, Xin Zhao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

36 Citations (Scopus)


Bone defect repair, due to its complex process in nature, has become a costly issue in modern day medicine. This causes a growing demand for a bone substitute that is effective and easy to construct. Recently, triply periodic minimal surface (TPMS) scaffolds, which embody trabecular bone-mimicking hyperboloidal topography, have become a promising candidate for this exact role due to their unique structure to promote many cellular processes. In response to the growing popularity of TPMS scaffolds amongst researchers, this review discusses the effect of different parameters (including pore size, porosity, and pore shape, as well as their influences on mechanical property, permeability, and curvature), along with the controlling and designing of such parameters, on bone regeneration to serve as a guide for future researchers in designing and utilizing TPMS scaffolds for bone regeneration purposes.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalEngineered Regeneration
Publication statusPublished - 30 Sept 2021


  • Bone regeneration
  • Pore structure
  • TPMS scaffolds

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials


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