Application of thermosensitive poloxamer-based hydrogel in the development of transdermal therapy containing herbal medicine

Wenyi Wang, Chi Leung Hui, Frency S.F. Ng, Chi Wai Kan, Clara B.S. Lau, Ping Chung Leung

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Poloxamer 407 exhibits remarkable reversible sol gel transition which makes it attractive and promising in the application of transdermal therapy. This study mainly reports the skin permeation properties of model drug from poloxamer 407 based transdermal hydrogel therapy with the presence of chemical penetration enhancers. Poloxamer 407 based hydrogel was shown porous structure which faciliates the diffusional release of model drug. Compared with borneol and 1,2-propanediol, azone was the most effective enhancer for gallic acid skin permeation, and 3% of azone presented the optimal enhancement effect. This study also demonstrated that the selection of enhancers is of great importance for the skin permeation of model drug.
Original languageEnglish
Title of host publicationAdvanced Materials Research and Technologies
PublisherTrans Tech Publications Ltd
Pages57-61
Number of pages5
ISBN (Print)9783035710052
DOIs
Publication statusPublished - 1 Jan 2017
EventInternational Conference on Advanced Materials Research and Manufacturing Technologies, AMRMT 2016 - Singapore, Singapore
Duration: 18 Aug 201620 Aug 2016

Publication series

NameKey Engineering Materials
Volume719
ISSN (Print)1013-9826

Conference

ConferenceInternational Conference on Advanced Materials Research and Manufacturing Technologies, AMRMT 2016
Country/TerritorySingapore
CitySingapore
Period18/08/1620/08/16

Keywords

  • Azone
  • Chemical enhancer
  • Poloxamer hydrogel
  • Transdermal therapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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