Apolipoprotein E ?4 allele is associated with vascular dementia

L. Baum, L.C.W. Lam, T. Kwok, J. Lee, H.F.K. Chiu, V.C.T. Mok, A. Wong, Xiangyan Chen, S.C. Wing, P.P. Chi, L.M. Suk, N.L.S. Tang, S.W. Ka, K.N. Ho

Research output: Journal article publicationJournal articleAcademic researchpeer-review

46 Citations (Scopus)

Abstract

Background/Aims: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. Methods: We genotyped ApoE in 144 VaD patients and 251 controls. Results: VaD patients were more likely than controls to have ApoE ?3/?4 or ?4/?4 genotypes: 23.6% versus 15.1%, odds ratio (OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of ?3/?4 or ?4/?4 genotypes with VaD was strong among people with hypertension (OR = 2.9, p = 0.007) or diabetes (OR = 6.5, p = 0.011). The association was absent among people without hypertension (OR = 1.1, p = 0.79) or diabetes (OR = 1.3, p = 0.43). Conclusion: This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation. Copyright © 2006 S. Karger AG.
Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume22
Issue number4
DOIs
Publication statusPublished - 1 Oct 2006
Externally publishedYes

Keywords

  • Apolipoprotein E
  • Apolipoprotein E, allele
  • Apolipoprotein E, genotype
  • Dementia, vascular
  • Diabetes
  • Hypertension
  • Polymorphism

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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