Apolipoprotein E ?4 allele is associated with vascular dementia

L. Baum; L.C.W. Lam; T. Kwok; J. Lee; H.F.K. Chiu; V.C.T. Mok; A. Wong; Xiangyan Chen; S.C. Wing; P.P. Chi; L.M. Suk; N.L.S. Tang; S.W. Ka; K.N. Ho

doi:10.1159/000095246

Apolipoprotein E ?4 allele is associated with vascular dementia

L. Baum, L.C.W. Lam, T. Kwok, J. Lee, H.F.K. Chiu, V.C.T. Mok, A. Wong, Xiangyan Chen, S.C. Wing, P.P. Chi, L.M. Suk, N.L.S. Tang, S.W. Ka, K.N. Ho

Research output: Journal article publication › Journal article › Academic research › peer-review

51 Citations (Scopus)

Abstract

Background/Aims: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. Methods: We genotyped ApoE in 144 VaD patients and 251 controls. Results: VaD patients were more likely than controls to have ApoE ?3/?4 or ?4/?4 genotypes: 23.6% versus 15.1%, odds ratio (OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of ?3/?4 or ?4/?4 genotypes with VaD was strong among people with hypertension (OR = 2.9, p = 0.007) or diabetes (OR = 6.5, p = 0.011). The association was absent among people without hypertension (OR = 1.1, p = 0.79) or diabetes (OR = 1.3, p = 0.43). Conclusion: This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation. Copyright © 2006 S. Karger AG.

Original language	English
Pages (from-to)	301-305
Number of pages	5
Journal	Dementia and Geriatric Cognitive Disorders
Volume	22
Issue number	4
DOIs	https://doi.org/10.1159/000095246
Publication status	Published - 1 Oct 2006
Externally published	Yes

Keywords

Apolipoprotein E
Apolipoprotein E, allele
Apolipoprotein E, genotype
Dementia, vascular
Diabetes
Hypertension
Polymorphism

ASJC Scopus subject areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1159/000095246

Cite this

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title = "Apolipoprotein E ?4 allele is associated with vascular dementia",

abstract = "Background/Aims: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. Methods: We genotyped ApoE in 144 VaD patients and 251 controls. Results: VaD patients were more likely than controls to have ApoE ?3/?4 or ?4/?4 genotypes: 23.6% versus 15.1%, odds ratio (OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of ?3/?4 or ?4/?4 genotypes with VaD was strong among people with hypertension (OR = 2.9, p = 0.007) or diabetes (OR = 6.5, p = 0.011). The association was absent among people without hypertension (OR = 1.1, p = 0.79) or diabetes (OR = 1.3, p = 0.43). Conclusion: This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation. Copyright {\textcopyright} 2006 S. Karger AG.",

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author = "L. Baum and L.C.W. Lam and T. Kwok and J. Lee and H.F.K. Chiu and V.C.T. Mok and A. Wong and Xiangyan Chen and S.C. Wing and P.P. Chi and L.M. Suk and N.L.S. Tang and S.W. Ka and K.N. Ho",

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language = "English",

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T1 - Apolipoprotein E ?4 allele is associated with vascular dementia

AU - Baum, L.

AU - Lam, L.C.W.

AU - Kwok, T.

AU - Lee, J.

AU - Chiu, H.F.K.

AU - Mok, V.C.T.

AU - Wong, A.

AU - Chen, Xiangyan

AU - Wing, S.C.

AU - Chi, P.P.

AU - Suk, L.M.

AU - Tang, N.L.S.

AU - Ka, S.W.

AU - Ho, K.N.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Background/Aims: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. Methods: We genotyped ApoE in 144 VaD patients and 251 controls. Results: VaD patients were more likely than controls to have ApoE ?3/?4 or ?4/?4 genotypes: 23.6% versus 15.1%, odds ratio (OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of ?3/?4 or ?4/?4 genotypes with VaD was strong among people with hypertension (OR = 2.9, p = 0.007) or diabetes (OR = 6.5, p = 0.011). The association was absent among people without hypertension (OR = 1.1, p = 0.79) or diabetes (OR = 1.3, p = 0.43). Conclusion: This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation. Copyright © 2006 S. Karger AG.

AB - Background/Aims: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. Methods: We genotyped ApoE in 144 VaD patients and 251 controls. Results: VaD patients were more likely than controls to have ApoE ?3/?4 or ?4/?4 genotypes: 23.6% versus 15.1%, odds ratio (OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of ?3/?4 or ?4/?4 genotypes with VaD was strong among people with hypertension (OR = 2.9, p = 0.007) or diabetes (OR = 6.5, p = 0.011). The association was absent among people without hypertension (OR = 1.1, p = 0.79) or diabetes (OR = 1.3, p = 0.43). Conclusion: This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation. Copyright © 2006 S. Karger AG.

KW - Apolipoprotein E

KW - Apolipoprotein E, allele

KW - Apolipoprotein E, genotype

KW - Dementia, vascular

KW - Diabetes

KW - Hypertension

KW - Polymorphism

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DO - 10.1159/000095246

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SN - 1420-8008

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JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 4

ER -

Apolipoprotein E ?4 allele is associated with vascular dementia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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