Antioxidant and hypoglycemic activities of exopolysaccharide by submerged culture of inocutus hispidus

S. H. Liu, S. W. Sun, Z. F. Tian, Jianyong Wu, X. L. Li, C. P. Xu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

This work was to investigate the hypoglycemic and antioxidant activities of the exopolysaccharides produced in a stirred-tank bioreactor by Inocutus hispidus. The exopolysaccharides showed significant antioxidant activities, up to 70.7±2.5% inhibition of hydroxyl radicals, 50% inhibition of 2,2-diphenyl-1-picrylhydrazyl radicals, and a Trolox equivalent antioxidant capacity of 3.3 mM. The exopolysaccharide also showed notable hypoglycemic effects in streptozotocin-induced diabetic mice, reducing the plasma glucose, total cholesterol and triacylglycerol concentrations by 18.2±1.5, 20.9±0.8 and 14.4±0.4, respectively. The results demonstrated the potential of this EPS for human health protection against oxidative damage and hyperglycemia.
Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume77
Issue number3
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • antioxidant
  • Exopolysaccharides
  • fermentation
  • hypoglycemic effect
  • Inocutus hispidus

ASJC Scopus subject areas

  • Pharmaceutical Science

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