Antibacterial Radicicol Analogues from Pochonia chlamydosporia and Their Biosynthetic Gene Cluster

Ka Man Yip, Jun Xu, Shan Shan Zhou, Yuk Man Lau, Qi Lei Chen, Yan Cheng Tang, Zhi Jun Yang, Zhong Ping Yao, Ping Ding, Hu Biao Chen, Zhong Zhen Zhao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)


Chemical investigation of fungus Pochonia chlamydosporia strain 170, derived from rice fermentation sediment samples, afforded seven radicicol analogues, including two new compounds, monocillin VI (1) and monocillin VII (2), and five known compounds, monocillin II (3), monorden D (4), monocillin IV (5), monocillin V (6), and pochonin M (7). The structures of compounds 1-7 were established primarily by analysis of nuclear magnetic resonance data, and the absolute configurations of the secondary alcohol in compounds 1 and 2 were assigned by the modified Mosher method. All seven compounds have modest antibacterial activities, with a minimal inhibitory concentration (MIC) of 25.6 μg/mL for compounds 1 and 3-7 and 51.2 μg/mL for compound 2, on inhibition of the growth of the plant pathogen Xanthomonas campestris (the positive control ampicillin showed a MIC value of 12.8 μg/mL), indicating that the fungus has the potential to control bacterial disease. The biosynthetic gene cluster and putative biosynthetic pathways of these radicicol analogues in the P. chlamydosporia genome were proposed. These findings increase our knowledge of the chemical potential of P. chlamydosporia and may allow us to better utilize the fungus as a biological control agent.

Original languageEnglish
Pages (from-to)7266-7273
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Issue number26
Publication statusPublished - 3 Jul 2019


  • antibacterial activity
  • biosynthetic gene cluster
  • Pochonia chlamydosporia
  • radicicol analogues
  • Xanthomonas campestris pv. campestris

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences


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