Antibacterial nanosystems for cancer therapy

Jingdong Rao, Yuhe Yang, Ho Pan Bei, Chak Yin Tang, Xin Zhao

Research output: Journal article publicationReview articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Bacteria and cancer cells share a unique symbiotic relationship in the process of cancer development and treatment. It has been shown that certain bacteria can mediate cancer and thrive inside cancerous tissues. Moreover, during cancer treatment, microbial infections have been shown to impair the therapeutic efficacy and lead to serious complications. In the past decades, the application of antibiotics has achieved great success in fighting numerous bacteria but the administration route, low localization effects and related drug resistance limit the further utilization of antibiotics. Recently, advances in nanotechnology have made a significant impact in the medical field, which enhance the drug solubility and can target lesion sites, and some nanomaterials can even be applied as the therapeutic agent itself. In this review, we introduce anti-bacterial nanosystems for cancer therapy in the aspects of spontaneous and triggered anti-bacterial action, and our notions, as well as proposed research directions for the further development of this field, are discussed.

Original languageEnglish
Pages (from-to)6814-6824
Number of pages11
JournalBiomaterials Science
Volume8
Issue number24
DOIs
Publication statusPublished - 21 Dec 2020

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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