TY - JOUR
T1 - Antibacterial nanosystems for cancer therapy
AU - Rao, Jingdong
AU - Yang, Yuhe
AU - Pan Bei, Ho
AU - Tang, Chak Yin
AU - Zhao, Xin
N1 - Funding Information:
The work described in this paper was substantially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. PolyU 15202119) and partially supported by the intra-faculty fund (1-ZVPC) from the Hong Kong Polytechnic University.
Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2020/12/21
Y1 - 2020/12/21
N2 - Bacteria and cancer cells share a unique symbiotic relationship in the process of cancer development and treatment. It has been shown that certain bacteria can mediate cancer and thrive inside cancerous tissues. Moreover, during cancer treatment, microbial infections have been shown to impair the therapeutic efficacy and lead to serious complications. In the past decades, the application of antibiotics has achieved great success in fighting numerous bacteria but the administration route, low localization effects and related drug resistance limit the further utilization of antibiotics. Recently, advances in nanotechnology have made a significant impact in the medical field, which enhance the drug solubility and can target lesion sites, and some nanomaterials can even be applied as the therapeutic agent itself. In this review, we introduce anti-bacterial nanosystems for cancer therapy in the aspects of spontaneous and triggered anti-bacterial action, and our notions, as well as proposed research directions for the further development of this field, are discussed.
AB - Bacteria and cancer cells share a unique symbiotic relationship in the process of cancer development and treatment. It has been shown that certain bacteria can mediate cancer and thrive inside cancerous tissues. Moreover, during cancer treatment, microbial infections have been shown to impair the therapeutic efficacy and lead to serious complications. In the past decades, the application of antibiotics has achieved great success in fighting numerous bacteria but the administration route, low localization effects and related drug resistance limit the further utilization of antibiotics. Recently, advances in nanotechnology have made a significant impact in the medical field, which enhance the drug solubility and can target lesion sites, and some nanomaterials can even be applied as the therapeutic agent itself. In this review, we introduce anti-bacterial nanosystems for cancer therapy in the aspects of spontaneous and triggered anti-bacterial action, and our notions, as well as proposed research directions for the further development of this field, are discussed.
UR - http://www.scopus.com/inward/record.url?scp=85098457829&partnerID=8YFLogxK
U2 - 10.1039/d0bm01537g
DO - 10.1039/d0bm01537g
M3 - Review article
C2 - 33078786
AN - SCOPUS:85098457829
SN - 2047-4830
VL - 8
SP - 6814
EP - 6824
JO - Biomaterials Science
JF - Biomaterials Science
IS - 24
ER -
