TY - JOUR
T1 - Anti-Inflammatory Nutrition and Successful Ageing in Elderly Individuals
T2 - The Multinational MEDIS Study
AU - Tyrovolas, Stefanos
AU - Haro, Josep Maria
AU - Foscolou, Alexandra
AU - Tyrovola, Dimitra
AU - Mariolis, Anargiros
AU - Bountziouka, Vassiliki
AU - Piscopo, Suzanne
AU - Valacchi, Giuseppe
AU - Anastasiou, Foteini
AU - Gotsis, Efthimios
AU - Metallinos, George
AU - Papairakleous, Natassa
AU - Polychronopoulos, Evangelos
AU - Matalas, Antonia Leda
AU - Lionis, Christos
AU - Zeimbekis, Akis
AU - Tur, Josep Antoni
AU - Sidossis, Labros S.
AU - Panagiotakos, Demosthenes B.
N1 - Funding Information:
The Study was funded by Research grants from the Hellenic Heart Foundation, the Graduate Program of the Department of Nutrition & Dietetics, Harokopio University, and the Rutgers University, NJ, USA (GA #5884).
Publisher Copyright:
© 2017 S. Karger AG, Basel.
PY - 2017
Y1 - 2017
N2 - Background: The role of diet and inflammation in successful ageing is not transparent, and as such, is still being investigated. The aim of the present work was to evaluate the inflammatory potential of dietary habits in the successful ageing of a random sample of older adults living in the Mediterranean basin and who participated in the MEDIS (MEDiterranean ISlands) study. Methods: During 2005-2016, 3,128 older adults (aged 65-100 years) from 24 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were enrolled in the study. A multidimensional successful ageing index consisting of 10 components was employed. A validated and reproducible Food Frequency Questionnaire (FFQ) was used to evaluate the dietary habits of the older adults. A nutrition anti-inflammatory (NAI) score based on the participants' specific dietary habits was assessed. Results: Participants with high NAI scores (proinflammatory nutrition) had a higher prevalence of hypercholesterolemia and lower levels of successful ageing. After adjusting for several confounders, the NAI score was associated with successful ageing (-0.03, 95% CI -0.5 to -0.006). Stratified analysis by gender and advanced age revealed heterogeneity in the NAI score, predicting successful ageing. Conclusions: The inflammatory potential of nutrition was reported as an important factor for successful ageing, suggesting that further research is needed on the role of anti- and proinflammatory dietary habits in healthy and successful ageing.
AB - Background: The role of diet and inflammation in successful ageing is not transparent, and as such, is still being investigated. The aim of the present work was to evaluate the inflammatory potential of dietary habits in the successful ageing of a random sample of older adults living in the Mediterranean basin and who participated in the MEDIS (MEDiterranean ISlands) study. Methods: During 2005-2016, 3,128 older adults (aged 65-100 years) from 24 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were enrolled in the study. A multidimensional successful ageing index consisting of 10 components was employed. A validated and reproducible Food Frequency Questionnaire (FFQ) was used to evaluate the dietary habits of the older adults. A nutrition anti-inflammatory (NAI) score based on the participants' specific dietary habits was assessed. Results: Participants with high NAI scores (proinflammatory nutrition) had a higher prevalence of hypercholesterolemia and lower levels of successful ageing. After adjusting for several confounders, the NAI score was associated with successful ageing (-0.03, 95% CI -0.5 to -0.006). Stratified analysis by gender and advanced age revealed heterogeneity in the NAI score, predicting successful ageing. Conclusions: The inflammatory potential of nutrition was reported as an important factor for successful ageing, suggesting that further research is needed on the role of anti- and proinflammatory dietary habits in healthy and successful ageing.
KW - Dietary habits
KW - Inflammation
KW - Mediterranean basin
KW - Older adults
KW - Successful ageing
UR - http://www.scopus.com/inward/record.url?scp=85029445632&partnerID=8YFLogxK
U2 - 10.1159/000479065
DO - 10.1159/000479065
M3 - Journal article
C2 - 28898883
AN - SCOPUS:85029445632
SN - 0304-324X
VL - 64
SP - 3
EP - 10
JO - Gerontology
JF - Gerontology
IS - 1
ER -