Anti-HIV-1 nanotherapeutics: Promises and challenges for the future

Supriya D. Mahajan, Ravikumar Aalinkeel, Wing Cheung Law, Jessica L. Reynolds, Bindukumar B. Nair, Donald E. Sykes, Ken Tye Yong, Indrajit Roy, Paras N. Prasad, Stanley A. Schwartz

Research output: Journal article publicationReview articleAcademic researchpeer-review

92 Citations (Scopus)

Abstract

The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the virus remains sequestered in anatomically privileged sites within the body. Nanotechnology-based delivery systems are being developed to target the virus within different tissue compartments and are being evaluated for their safety and efficacy. The current review outlines the various nanomaterials that are becoming increasingly used in biomedical applications by virtue of their robustness, safety, multimodality, and multifunctionality. Nanotechnology can revolutionize the field of HIV medicine by not only improving diagnosis, but also by improving delivery of antiretrovirals to targeted regions in the body and by significantly enhancing the efficacy of the currently available antiretroviral medications.
Original languageEnglish
Pages (from-to)5301-5314
Number of pages14
JournalInternational Journal of Nanomedicine
Volume7
DOIs
Publication statusPublished - 5 Dec 2012
Externally publishedYes

Keywords

  • Drug delivery
  • HAART
  • HIV
  • Nano
  • Nanomedicine
  • Nanotherapeutics

ASJC Scopus subject areas

  • Bioengineering
  • Biophysics
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry

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