Analysis of the topological characteristics of a protein-protein interaction network

Yuanyuan Sun; Yujie Zhao; Chi Kong Tse; Chung Ming Lau

doi:10.1109/IWCFTA.2012.36

Analysis of the topological characteristics of a protein-protein interaction network

Yuanyuan Sun, Yujie Zhao, Chi Kong Tse, Chung Ming Lau

The Hong Kong Polytechnic University

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

1 Citation (Scopus)

Abstract

The Protein-Protein Interaction networks are the typical complex biological networks, and the analysis of their topological characteristics is one of the most important and widely discussed research topics today. This paper analyzes the topological characteristics of a PPI network based on the theory of complex networks, focusing on degree distribution, average path length, network diameter, clustering coefficient, degree correlations as well as fractality. The experimental results show that this PPI network has the typical scale-free and small-world distributions, low clustering coefficient, negative correlation, but it has no fractal feature.

Original language	English
Title of host publication	Proceedings of the 5th International Workshop on Chaos-Fractals Theories and Applications, IWCFTA 2012
Pages	127-130
Number of pages	4
DOIs	https://doi.org/10.1109/IWCFTA.2012.36
Publication status	Published - 1 Dec 2012
Event	5th International Workshop on Chaos-Fractals Theories and Applications, IWCFTA 2012 - Dalian, Liaoning, China Duration: 18 Oct 2012 → 21 Oct 2012

Conference

Conference	5th International Workshop on Chaos-Fractals Theories and Applications, IWCFTA 2012
Country/Territory	China
City	Dalian, Liaoning
Period	18/10/12 → 21/10/12

Keywords

correlations
fractal
PPI networks
scale-free
small-world
topological analysis

ASJC Scopus subject areas

Computational Theory and Mathematics
Applied Mathematics

More information

10.1109/IWCFTA.2012.36

Cite this

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title = "Analysis of the topological characteristics of a protein-protein interaction network",

abstract = "The Protein-Protein Interaction networks are the typical complex biological networks, and the analysis of their topological characteristics is one of the most important and widely discussed research topics today. This paper analyzes the topological characteristics of a PPI network based on the theory of complex networks, focusing on degree distribution, average path length, network diameter, clustering coefficient, degree correlations as well as fractality. The experimental results show that this PPI network has the typical scale-free and small-world distributions, low clustering coefficient, negative correlation, but it has no fractal feature.",

keywords = "correlations, fractal, PPI networks, scale-free, small-world, topological analysis",

author = "Yuanyuan Sun and Yujie Zhao and Tse, {Chi Kong} and Lau, {Chung Ming}",

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day = "1",

doi = "10.1109/IWCFTA.2012.36",

language = "English",

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pages = "127--130",

booktitle = "Proceedings of the 5th International Workshop on Chaos-Fractals Theories and Applications, IWCFTA 2012",

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Sun, Y, Zhao, Y, Tse, CK & Lau, CM 2012, Analysis of the topological characteristics of a protein-protein interaction network. in Proceedings of the 5th International Workshop on Chaos-Fractals Theories and Applications, IWCFTA 2012., 6383260, pp. 127-130, 5th International Workshop on Chaos-Fractals Theories and Applications, IWCFTA 2012, Dalian, Liaoning, China, 18/10/12. https://doi.org/10.1109/IWCFTA.2012.36

Analysis of the topological characteristics of a protein-protein interaction network. / Sun, Yuanyuan; Zhao, Yujie; Tse, Chi Kong et al.
Proceedings of the 5th International Workshop on Chaos-Fractals Theories and Applications, IWCFTA 2012. 2012. p. 127-130 6383260.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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AU - Lau, Chung Ming

PY - 2012/12/1

Y1 - 2012/12/1

N2 - The Protein-Protein Interaction networks are the typical complex biological networks, and the analysis of their topological characteristics is one of the most important and widely discussed research topics today. This paper analyzes the topological characteristics of a PPI network based on the theory of complex networks, focusing on degree distribution, average path length, network diameter, clustering coefficient, degree correlations as well as fractality. The experimental results show that this PPI network has the typical scale-free and small-world distributions, low clustering coefficient, negative correlation, but it has no fractal feature.

AB - The Protein-Protein Interaction networks are the typical complex biological networks, and the analysis of their topological characteristics is one of the most important and widely discussed research topics today. This paper analyzes the topological characteristics of a PPI network based on the theory of complex networks, focusing on degree distribution, average path length, network diameter, clustering coefficient, degree correlations as well as fractality. The experimental results show that this PPI network has the typical scale-free and small-world distributions, low clustering coefficient, negative correlation, but it has no fractal feature.

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Analysis of the topological characteristics of a protein-protein interaction network

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Keywords

ASJC Scopus subject areas

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