Analysis of aprepitant for prevention of chemotherapy-induced nausea and vomiting with moderately and highly emetogenic chemotherapy

Alexandros Molasiotis, Allison Martin Nguyen, Cynthia N. Rittenberg, Alex Makalinao, Alexandra Carides

Research output: Journal article publicationJournal articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Aim: This study aimed to determine how aprepitant affects the impact of chemotherapy-induced nausea and vomiting (CINV) on daily activities during highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC). Patients & methods: Patients received aprepitant plus standard antiemetic therapy (ondansetron plus dexamethasone) or standard antiemetic therapy alone. Data were analyzed from pooled data of two Phase III randomized, double-blind HEC trials and one MEC trial. Patients completed the Functional Living Index-Emesis questionnaire. Results: A significantly greater percentage of patients receiving aprepitant reported no or minimal CINV impact on daily life (overall total Functional Living Index-Emesis score >6) compared with those receiving standard therapy alone (HEC: 74.4 vs 63.9%, respectively; p < 0.01; MEC: 73.4 vs 66.3%; p < 0.05). In HEC, favorable responses to aprepitant treatment persisted in nausea (70.2 vs 60.9%) and vomiting domains (84.6 vs 68.7%; both p < 0.01). Similar results were seen in MEC. Conclusion: Addition of aprepitant reduced CINV impact on daily life compared with standard antiemetic therapy.
Original languageEnglish
Pages (from-to)1443-1450
Number of pages8
JournalFuture Oncology
Volume9
Issue number10
DOIs
Publication statusPublished - 1 Oct 2013
Externally publishedYes

Keywords

  • antiemetic
  • nausea
  • patient outcomes
  • quality of life
  • vomiting

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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