An ultrasensitive and selective fluorescent nanosensor based on porphyrinic metal-organic framework nanoparticles for Cu2+ detection

Changming Cheng, Ruolin Zhang, Jiuhai Wang, Yu Zhang, Chunyi Wen, Youhua Tan, Mo Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)


Detecting trace amounts of copper ions (Cu2+) is of high importance since copper is an essential element in the environment and the human body. Despite the recent advances in Cu2+ detection, the current approaches still suffer from insensitivity and lack of in situ detection in living cells. In the present work, a fluorescent nanosensor based on porphyrinic metal-organic framework nanoparticles (MOF-525 NPs) is proposed for sensitive and selective monitoring of Cu2+ in aqueous solution and living cells. The MOF-525 NPs with attractive properties, including ultrasmall size, good water dispersity and intense red fluorescence, are prepared via a facile and environment-friendly hydrothermal route. The fluorescence signal of MOF-525 NPs could be quenched statically by Cu2+ with high selectivity due to the strong affinity of Cu2+ to the porphyrin ligand in MOF-525. The proposed fluorescent nanosensor has a linear response in the range of 1.0-250 nM with a low detection limit of 220 pM. Furthermore, it is successfully employed for the detection of Cu2+ in water samples and the intracellular imaging of Cu2+ in living cells, demonstrating its great potential in the sensing and biological fields.

Original languageEnglish
Pages (from-to)797-804
Number of pages8
Issue number3
Publication statusPublished - 7 Feb 2020

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this