An innovative numerical approach to resolve the pulse wave velocity in a healthy thoracic aorta model

An Shik Yang, Chih-yung Wen, Li Yu Tseng, Chih Chieh Chiang, Wen Yih Isaac Tseng, Hsi Yu Yu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)


Aortic dissection and atherosclerosis are highly fatal diseases. The development of both diseases is closely associated with highly complex haemodynamics. Thus, in predicting the onset of cardiac disease, it is desirable to obtain a detailed understanding of the flowfield characteristics in the human cardiovascular circulatory system. Accordingly, in this study, a numerical model of a normal human thoracic aorta is constructed using the geometry information obtained from a phase-contrast magnetic resonance imaging (PC-MRI) technique. The interaction between the blood flow and the vessel wall dynamics is then investigated using a coupled fluid-structure interaction (FSI) analysis. The simulations focus specifically on the flowfield characteristics and pulse wave velocity (PWV) of the blood flow. Instead of using a conventional PC-MRI method to measure PWV, we present an innovative application of using the FSI approach to numerically resolve PWV for the assessment of wall compliance in a thoracic aorta model. The estimated PWV for a normal thoracic aorta agrees well with the results obtained via PC-MRI measurement. In addition, simulations which consider the FSI effect yield a lower predicted value of the wall shear stress at certain locations in the cardiac cycle than models which assume a rigid vessel wall. Consequently, the model provides a suitable basis for the future development of more sophisticated methods capable of performing the computer-aided analysis of aortic blood flows.
Original languageEnglish
Pages (from-to)461-473
Number of pages13
JournalComputer Methods in Biomechanics and Biomedical Engineering
Issue number5
Publication statusPublished - 1 Jan 2014
Externally publishedYes


  • fluid-structure interaction
  • haemodynamics
  • pulse wave velocity
  • thoracic aorta

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Human-Computer Interaction
  • Computer Science Applications


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