TY - JOUR
T1 - An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
AU - Chen, Hao
AU - Cheng, Ruoyu
AU - Zhao, Xin
AU - Zhang, Yuhui
AU - Tam, Allison
AU - Yan, Yufei
AU - Shen, Haokai
AU - Zhang, Yu Shrike
AU - Qi, Jin
AU - Feng, Yonghai
AU - Liu, Lei
AU - Pan, Guoqing
AU - Cui, Wenguo
AU - Deng, Lianfu
N1 - Funding Information:
H.C., R.C. and X.Z. contributed equally to this work. This work was financially supported by the National Key Research and Development Program of China (2018YFC1106200 and 2018YFC1106204), National Natural Science Foundation of China (81702125, 21875092, 81572099, 51873107, and 21574091), the “Six Talent Peaks” program of Jiangsu Province (2018-XCL-013), the Science and Technology Commission of Shanghai Municipality (18ZR1434200), the Shanghai Sailing Program (17YF1411300), the Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20171906), the Excellent Youth Scholars of Shanghai Jiao Tong University School of Medicine (17XJ11004), the Natural Science Foundation of Jiangsu Province (No. BK20160056), and the start-up fund (1-ZE7S) and central research fund (G-YBWS) from the Hong Kong Polytechnic University.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) with silver nitrate (AgNO3). Due to the dynamic nature of Ag-S coordination bond and bacteria-killing activity of Ag+, the resultant coordinative hydrogel featured self-healing, injectable and antibacterial properties. In this study, we synchronously loaded an angiogenic drug, desferrioxamine (DFO), in the coordinative hydrogel during cross-linking. We finally obtained a multifunctional hydrogel that is manageable, resistant to mechanical irritation, antibacterial and angiogenic in vitro. Our in vivo studies further demonstrated that the injectable self-healing hydrogel could efficiently repair diabetic skin wounds with low bacteria-infection and enhance angiogenic activity. In short, besides diabetic skin wound repair, such dynamic multifunctional hydrogel scaffolds would show great promise in the regeneration of different types of exposed wounds, in particular, in situations with disturbed physiological functions, high risk of bacterial infections, and external mechanical irritation.
AB - We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) with silver nitrate (AgNO3). Due to the dynamic nature of Ag-S coordination bond and bacteria-killing activity of Ag+, the resultant coordinative hydrogel featured self-healing, injectable and antibacterial properties. In this study, we synchronously loaded an angiogenic drug, desferrioxamine (DFO), in the coordinative hydrogel during cross-linking. We finally obtained a multifunctional hydrogel that is manageable, resistant to mechanical irritation, antibacterial and angiogenic in vitro. Our in vivo studies further demonstrated that the injectable self-healing hydrogel could efficiently repair diabetic skin wounds with low bacteria-infection and enhance angiogenic activity. In short, besides diabetic skin wound repair, such dynamic multifunctional hydrogel scaffolds would show great promise in the regeneration of different types of exposed wounds, in particular, in situations with disturbed physiological functions, high risk of bacterial infections, and external mechanical irritation.
UR - http://www.scopus.com/inward/record.url?scp=85060551157&partnerID=8YFLogxK
U2 - 10.1038/s41427-018-0103-9
DO - 10.1038/s41427-018-0103-9
M3 - Journal article
AN - SCOPUS:85060551157
SN - 1884-4049
VL - 11
JO - NPG Asia Materials
JF - NPG Asia Materials
IS - 1
M1 - 3
ER -
