@article{580db1fb7fb34e26b303ee4918eb922c,
title = "An indole-amide-based phosphine ligand enabling a general palladium-catalyzed sterically hindered Suzuki-Miyaura cross-coupling reaction",
abstract = "A novel family of indole-amide-based phosphine ligands was designed and synthesized. The Pd/InAm-phos (L1) catalytic system exhibited excellent efficiency in the Suzuki-Miyaura cross-coupling of sterically hindered (hetero)aryl chlorides to synthesize tri-ortho-substituted biaryls. Excellent product yields were obtained in a short reaction time (e.g., 10 min), and a Pd catalyst loading down to 50 ppm was also achieved. The oxidative addition adduct of Pd-L1 with 2-chlorotoluene was also well-characterized by single-crystal X-ray crystallography and showed a κ2-P,O-coordination of L1 with palladium.",
author = "Ng, {Shan Shan} and Zicong Chen and Yuen, {On Ying} and So, {Chau Ming}",
note = "Funding Information: We thank the Shenzhen Municipal Science and Technology Innovation Commission (JCYJ20180306173843318) and the National Natural Science Foundation of China (21972122) for financial support. The work described in this paper was also supported by the grants from the Research Grants Council of the Hong Kong Special Administrative Region, China (PolyU 15300220 and 25301819). We also thank Dr Ting-kwok Chan, Wesley (PolyU), for the X-ray analysis, Dr Pui-kin So (PolyU) for the HRMS analysis, and Dr Siu-cheong Yan, Kenneth (PolyU), for the NMR analysis. Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry",
year = "2022",
month = feb,
day = "21",
doi = "10.1039/d1ob02294f",
language = "English",
volume = "20",
pages = "1373--1378",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "7",
}