An essential role of innate lymphoid cells in the pathophysiology of graft-vs.-host disease

Liang Shao; Shan Pan; Qiu Ping Zhang; Muhammad Jamal; Lu Hua Chen; Qian Yin; Ying Jie Wu; Jie Xiong; Rui Jing Xiao; Yok Lam Kwong; Fu Ling Zhou; Albert K.W. Lie

doi:10.3389/fimmu.2019.01233

An essential role of innate lymphoid cells in the pathophysiology of graft-vs.-host disease

Liang Shao
, Shan Pan
, Qiu Ping Zhang
, Muhammad Jamal
, Lu Hua Chen
, Qian Yin
, Ying Jie Wu
, Jie Xiong
, Rui Jing Xiao
, Yok Lam Kwong
, Fu Ling Zhou (Corresponding Author)
, Albert K.W. Lie (Corresponding Author)

Research output: Journal article publication › Review article › Academic research › peer-review

13 Citations (Scopus)

Abstract

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.

Original language	English
Article number	1233
Journal	Frontiers in Immunology
Volume	10
Issue number	JUN
DOIs	https://doi.org/10.3389/fimmu.2019.01233
Publication status	Published - 9 Jun 2019
Externally published	Yes

Keywords

Graft-vs.-host disease
Hematopoietic stem cell transplantation
ILCreg
Innate lymphoid cells
NK cells
T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

More information

10.3389/fimmu.2019.01233

Cite this

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title = "An essential role of innate lymphoid cells in the pathophysiology of graft-vs.-host disease",

abstract = "Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.",

keywords = "Graft-vs.-host disease, Hematopoietic stem cell transplantation, ILCreg, Innate lymphoid cells, NK cells, T cells",

author = "Liang Shao and Shan Pan and Zhang, \{Qiu Ping\} and Muhammad Jamal and Chen, \{Lu Hua\} and Qian Yin and Wu, \{Ying Jie\} and Jie Xiong and Xiao, \{Rui Jing\} and Kwong, \{Yok Lam\} and Zhou, \{Fu Ling\} and Lie, \{Albert K.W.\}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No.81500151 and 81770179), the Natural Foundation of Hubei Province (China) (No.2017CFB631), and The Innovative Foundation of Zhongnan Hospital of Wuhan University (No. znpy2018025). Publisher Copyright: {\textcopyright} 2019 Shao, Pan, Zhang, Jamal, Chen, Yin, Wu, Xiong, Xiao, Kwong, Zhou and Lie.",

year = "2019",

month = jun,

day = "9",

doi = "10.3389/fimmu.2019.01233",

language = "English",

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TY - JOUR

T1 - An essential role of innate lymphoid cells in the pathophysiology of graft-vs.-host disease

AU - Shao, Liang

AU - Pan, Shan

AU - Zhang, Qiu Ping

AU - Jamal, Muhammad

AU - Chen, Lu Hua

AU - Yin, Qian

AU - Wu, Ying Jie

AU - Xiong, Jie

AU - Xiao, Rui Jing

AU - Kwong, Yok Lam

AU - Zhou, Fu Ling

AU - Lie, Albert K.W.

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No.81500151 and 81770179), the Natural Foundation of Hubei Province (China) (No.2017CFB631), and The Innovative Foundation of Zhongnan Hospital of Wuhan University (No. znpy2018025). Publisher Copyright: © 2019 Shao, Pan, Zhang, Jamal, Chen, Yin, Wu, Xiong, Xiao, Kwong, Zhou and Lie.

PY - 2019/6/9

Y1 - 2019/6/9

N2 - Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.

AB - Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.

KW - Graft-vs.-host disease

KW - Hematopoietic stem cell transplantation

KW - ILCreg

KW - Innate lymphoid cells

KW - NK cells

KW - T cells

UR - https://www.scopus.com/pages/publications/85068868342

U2 - 10.3389/fimmu.2019.01233

DO - 10.3389/fimmu.2019.01233

M3 - Review article

C2 - 31244831

AN - SCOPUS:85068868342

SN - 1664-3224

VL - 10

JO - Frontiers in Immunology

JF - Frontiers in Immunology

IS - JUN

M1 - 1233

ER -

An essential role of innate lymphoid cells in the pathophysiology of graft-vs.-host disease

Abstract

Keywords

ASJC Scopus subject areas

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