Abstract
This study describes an efficient class of hemilabile benzimidazolyl- phosphane ligands that can be easily accessed from commercially available and inexpensive starting materials. The application of this ligand array in the palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids is described. The palladium catalyst generated from this hemilabile phosphane is highly effective in the Suzuki-Miyaura coupling of unactivated aryl chlorides, and catalyst loadings as low as 1 ppm can be achieved. An efficient class of hemilabile benzimidazolyl-phosphane ligands were synthesized. The palladium catalyst generated from this hemilabile phosphane is highly effective in the Suzuki-Miyaura coupling of unactivated aryl chlorides, and catalyst loadings as low as 1 ppm can be achieved. KGaA, Weinheim.
Original language | English |
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Pages (from-to) | 4172-4177 |
Number of pages | 6 |
Journal | European Journal of Organic Chemistry |
Issue number | 22 |
DOIs | |
Publication status | Published - 1 Aug 2012 |
Keywords
- Cross-coupling
- Ligand design
- N,P ligands
- Palladium
- Phosphanes
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry