An efficient class of P,N-type "phMezole-phos" ligands: Applications in palladium-catalyzed Suzuki coupling of aryl chlorides

Shun Man Wong, Chau Ming So, Kin Ho Chung, Chak Po Lau, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

36 Citations (Scopus)

Abstract

This study describes an efficient class of hemilabile benzimidazolyl- phosphane ligands that can be easily accessed from commercially available and inexpensive starting materials. The application of this ligand array in the palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids is described. The palladium catalyst generated from this hemilabile phosphane is highly effective in the Suzuki-Miyaura coupling of unactivated aryl chlorides, and catalyst loadings as low as 1 ppm can be achieved. An efficient class of hemilabile benzimidazolyl-phosphane ligands were synthesized. The palladium catalyst generated from this hemilabile phosphane is highly effective in the Suzuki-Miyaura coupling of unactivated aryl chlorides, and catalyst loadings as low as 1 ppm can be achieved. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)4172-4177
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number22
DOIs
Publication statusPublished - 1 Aug 2012

Keywords

  • Cross-coupling
  • Ligand design
  • N,P ligands
  • Palladium
  • Phosphanes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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