An Approach to the Welwistatin Core via a Diazoketone Rearrangement-Ring Expansion Strategy

Shuk Mei Lam; Wing Tak Wong; Pauline Chiu

doi:10.1021/acs.orglett.7b01988

An Approach to the Welwistatin Core via a Diazoketone Rearrangement-Ring Expansion Strategy

Shuk Mei Lam
, Wing Tak Wong
, Pauline Chiu

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

9 Citations (Scopus)

Abstract

The rhodium-catalyzed decomposition of fused bicyclic α-diazo-β-hydroxyketone 16 and rearrangement to 17 is featured in an approach to the bridged bicyclic core of welwistatin. The bicyclic [4.3.1] core of 25 is furnished from a subsequent cyclopropanation to generate 23, followed by its ring expansion.

Original language	English
Pages (from-to)	4468-4471
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	17
DOIs	https://doi.org/10.1021/acs.orglett.7b01988
Publication status	Published - 1 Sept 2017

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.7b01988

http://hdl.handle.net/10397/101581

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abstract = "The rhodium-catalyzed decomposition of fused bicyclic α-diazo-β-hydroxyketone 16 and rearrangement to 17 is featured in an approach to the bridged bicyclic core of welwistatin. The bicyclic [4.3.1] core of 25 is furnished from a subsequent cyclopropanation to generate 23, followed by its ring expansion.",

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AU - Chiu, Pauline

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AB - The rhodium-catalyzed decomposition of fused bicyclic α-diazo-β-hydroxyketone 16 and rearrangement to 17 is featured in an approach to the bridged bicyclic core of welwistatin. The bicyclic [4.3.1] core of 25 is furnished from a subsequent cyclopropanation to generate 23, followed by its ring expansion.

UR - https://www.scopus.com/pages/publications/85028749489

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DO - 10.1021/acs.orglett.7b01988

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An Approach to the Welwistatin Core via a Diazoketone Rearrangement-Ring Expansion Strategy

Abstract

ASJC Scopus subject areas

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