An approach of cancer cells diagnosis using biophotonic chip

X. J. Liang; Xuming Zhang; N. Ni; A. Q. Liu

doi:10.1117/12.631903

An approach of cancer cells diagnosis using biophotonic chip

X. J. Liang, Xuming Zhang, N. Ni, A. Q. Liu

Research output: Journal article publication › Conference article › Academic research › peer-review

1 Citation (Scopus)

Abstract

This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.

Original language	English
Article number	599404
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5994
DOIs	https://doi.org/10.1117/12.631903
Publication status	Published - 1 Dec 2005
Externally published	Yes
Event	Chemical and Biological Sensors for Industrial and Environmental Security - Boston, MA, United States Duration: 24 Oct 2005 → 26 Oct 2005

Keywords

External cavity laser
Microfluidics
Microlens
Refractive index
Single living cell

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1117/12.631903

Cite this

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title = "An approach of cancer cells diagnosis using biophotonic chip",

abstract = "This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.",

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author = "Liang, {X. J.} and Xuming Zhang and N. Ni and Liu, {A. Q.}",

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AU - Liang, X. J.

AU - Zhang, Xuming

AU - Ni, N.

AU - Liu, A. Q.

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Y1 - 2005/12/1

N2 - This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.

AB - This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.

KW - External cavity laser

KW - Microfluidics

KW - Microlens

KW - Refractive index

KW - Single living cell

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DO - 10.1117/12.631903

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VL - 5994

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

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T2 - Chemical and Biological Sensors for Industrial and Environmental Security

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An approach of cancer cells diagnosis using biophotonic chip

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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