An approach of cancer cells diagnosis using biophotonic chip

X. J. Liang, Xuming Zhang, N. Ni, A. Q. Liu

Research output: Journal article publicationConference articleAcademic researchpeer-review

1 Citation (Scopus)


This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.
Original languageEnglish
Article number599404
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 1 Dec 2005
Externally publishedYes
EventChemical and Biological Sensors for Industrial and Environmental Security - Boston, MA, United States
Duration: 24 Oct 200526 Oct 2005


  • External cavity laser
  • Microfluidics
  • Microlens
  • Refractive index
  • Single living cell

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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