Abstract
To study the relationship between the aldose reductase gene and diabetic complications, an (A-C)(n) dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
Original language | English |
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Pages (from-to) | 727-732 |
Number of pages | 6 |
Journal | Diabetes |
Volume | 44 |
Issue number | 7 |
Publication status | Published - 1 Jan 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism