An (A-C)(n) dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients

Chi Bun Ko, K. S L Lam, N. M S Wat, S. S M Chung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

148 Citations (Scopus)

Abstract

To study the relationship between the aldose reductase gene and diabetic complications, an (A-C)(n) dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalDiabetes
Volume44
Issue number7
Publication statusPublished - 1 Jan 1995
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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