Alternative mRNA splicing in the pathogenesis of obesity

Chi Ming Wong, Lu Xu, Mabel Yin Chun Yau

Research output: Journal article publicationReview articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

Alternative mRNA splicing is an important mechanism in expansion of proteome diversity by production of multiple protein isoforms. However, emerging evidence indicates that only a limited number of annotated protein isoforms by alternative splicing are detected, and the coding sequence of alternative splice variants usually is only slightly different from that of the canonical sequence. Nevertheless, mis-splicing is associated with a large array of human diseases. Previous reviews mainly focused on hereditary and somatic mutations in cis-acting RNA sequence elements and trans-acting splicing factors. The importance of environmental perturbations contributed to mis-splicing is not assessed. As significant changes in exon skipping and splicing factors expression levels are observed with diet-induced obesity, this review focuses on several well-known alternatively spliced metabolic factors and discusses recent advances in the regulation of the expressions of splice variants under the pathophysiological conditions of obesity. The potential of targeting the alternative mRNA mis-splicing for obesity-associated diseases therapies will also be discussed.

Original languageEnglish
Article number632
JournalInternational Journal of Molecular Sciences
Volume19
Issue number2
DOIs
Publication statusPublished - 23 Feb 2018

Keywords

  • Alternative mRNA splicing
  • Fox-1 Homolog 2
  • Insulin receptor
  • Leptin receptor
  • Lipin-1
  • LMNA
  • NOVA splicing factors
  • Nuclear receptor corepressor
  • Obesity-related diseases
  • RNA binding protein
  • Splice variants
  • Splicing factors

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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