ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Keyphrases

• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
• SQSTM1 100%
• Selective Autophagy 100%
• Amyotrophic Lateral Sclerosis 100%
• Anti-oxidative Stress 100%
• Frontotemporal Lobar Degeneration 100%
• Oxidative Stress Pathway 100%
• NFE2L2 100%
• TANK-binding Kinase 1 (TBK1) 45%
• Autophagy 36%
• Kelch-like ECH-associated Protein 1 (Keap1) 36%
• Phosphorylation 27%
• Autophagy Receptor 27%
• Cargo 18%
• Heme oxygenase-1 (HO-1) 18%
• Neurotoxicity 18%
• Superoxide Dismutase 1 (SOD1) 18%
• ULK1 18%
• GSTM1 18%
• TAR DNA-binding Protein 43 (TDP-43) 18%
• TARDBP 18%
• NBR1 18%
• Digestion 9%
• Associated Proteins 9%
• Serum Starvation 9%
• Neurodegenerative Diseases 9%
• Binding Protein 9%
• Pathogenic Mechanism 9%
• Oxidative Stress 9%
• Serine-threonine Kinase 9%
• SH3 Domain 9%
• Ubiquitin 9%
• GTPase-activating Protein 9%
• Dehydrogenase 9%
• Target Gene Expression 9%
• Quinones 9%
• Cargo Binding 9%
• Interaction Region 9%
• Autophagosome 9%
• Dendrite Morphology 9%
• Kelch-like 9%
• Autophagy Pathway 9%
• Macroautophagy 9%
• Protein Aggregates 9%
• Proteotoxic Stress 9%
• Proteostasis 9%
• Microtubule-associated Protein 1 Light Chain 3 9%
• Impaired Autophagy 9%
• Disease-causing mutations 9%
• Stress Granule Formation 9%
• Oxidative Stress Response 9%
• Cargo Receptor 9%
• NQO1 9%
• TAR DNA-binding Protein 9%
• Maltose-binding Protein 9%
• Unc-51-like Kinase 1 9%
• G3BP1 9%
• UBA Domain 9%
• NAD(P) 9%
• Catabolic Pathway 9%
• MAP1LC3B 9%
• Co-immunoprecipitation (co-IP) 9%

Biochemistry, Genetics and Molecular Biology

• Oxidative Stress 100%
• Selective Autophagy 100%
• NFE2L2 100%
• Autophagy 100%
• KEAP1 44%
• Kinase 44%
• Phosphotransferase 44%
• Transcription Factor Nrf2 33%
• Synapsin I 33%
• ULK1 22%
• TARDBP 22%
• Transactive Response Dna Binding Protein-43 22%
• NBR1 22%
• Wild Type 11%
• Binding Protein 11%
• Immunoprecipitation 11%
• GTPase-activating Protein 11%
• Nomenclature 11%
• Stress Granule 11%
• NAD(P)H Dehydrogenase (Quinone 1) 11%
• Glutathione S-Transferase Mu 1 11%
• Microtubule-Associated Protein 11%
• Gene Expression 11%
• Autophagosome 11%
• Light Chain 11%
• SOD1 11%
• Protein Homeostasis 11%
• Macroautophagy 11%
• TANK-binding Kinase 1 11%
• Maltose-Binding Protein 11%
• TAR DNA Binding Protein 11%
• SH3 Domain 11%
• Heme Oxygenase 11%
• Superoxide Dismutase 11%
• Sequestosome 1 11%
• Ubiquitin 11%
• Serine 11%
• Threonine 11%