Airborne transmission as an integral environmental dimension of antimicrobial resistance through the “One Health” lens

Ling Jin, Jiawen Xie, Tangtian He, Dong Wu, Xiangdong Li

Research output: Journal article publicationReview articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

As a quintessential “One Health” issue, antimicrobial resistance (AMR) can be transmitted in the environment via multiple pathways, thereby constituting an integral dimension of the human-animal-environment loop. Only recently has air been recognized as a potentially important pathway for the dissemination of antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria. This review presents the current know-how about the hypothesized dissemination from emission sources to human airways in association with influencing environmental factors and the consequent health implications. The presence of ARGs in source-specific and ambient air is no longer in question. The transport propensity of antibiotic-resistant bacteria needs to be quantified in order to assess the magnitude of the inhalation exposure of occupational and general populations. Reactive atmospheric components and prevailing meteorological conditions strongly influence the dynamics of and exposure to ambient inhalable ARGs. Considering the evolving trends of air pollution and climate change, such impacts on antibiotic-resistant pathogens need to be systematically studied. The ultimate question is the fate and consequences of inhalable AMR in interaction with microbiomes in healthy and diseased human airways, which would shed light on the role of AMR in viral-bacterial co-infections leading to acute and chronic respiratory diseases. We put forward a holistic methodological framework to address the major research gaps to establish the airborne transmission chain of antimicrobial resistance. An advanced understanding of these issues will be of benefit in devising effective control and management measures to minimize the airborne transmission of AMR, an integral environmental dimension to protecting the health of large populations.

Original languageEnglish
JournalCritical Reviews in Environmental Science and Technology
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • aerosolization
  • Antibiotic resistance gene
  • antibiotic-resistant bacteria
  • Frederic Coulon and Lena Ma
  • horizontal gene transfer
  • inhalation exposure
  • public health

ASJC Scopus subject areas

  • Environmental Engineering
  • Water Science and Technology
  • Waste Management and Disposal
  • Pollution

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