Age-related differences in response regulation as revealed by functional MRI

Tatia M C Lee, John X. Zhang, Che Hin Chan, Kenneth S L Yuen, L. W. Chu, Raymond T F Cheung, Y. S. Chan, Peter T. Fox, Jia Hong Gao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

24 Citations (Scopus)


This fMRI study studied age-related differences in neural activities during response regulation. Twenty-one male participants from two age groups, a younger group and an older group (mean ages: 29.9 and 65.2 years, respectively), were scanned while performing a task with response compatibility manipulation. They were presented with a sequence of arrowheads that pointed either upward or downward. In the "Response Compatible" condition, they were required to press an up or a down button consistent with the direction of the arrowhead. In the "Response Incompatible" condition, they were required to press the button opposite to the arrowhead direction so that an upward arrow should elicit a down response, and vice versa. Findings showed age-related differences in response regulation in several brain regions, including the right frontal, the right cingulate, and the left inferior parietal cortexes. The findings suggested a higher level of neural activity in the right prefrontal and left inferior parietal regions during response regulation for the older adults than for the younger adults.
Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalBrain Research
Issue number1
Publication statusPublished - 3 Mar 2006


  • Ageing
  • Functional magnetic resonance imaging
  • Habitual response
  • Inhibition
  • Response regulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology


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