Advances in rapid detection of SARS-CoV-2 by mass spectrometry

Tsz Fung Wong, Pui Kin So, Zhong Ping Yao

Research output: Journal article publicationReview articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

COVID-19 has already been lasting for more than two years and it has been severely affecting the whole world. Still, detection of SARS-CoV-2 remains the frontline approach to combat the pandemic, and the reverse transcription polymerase chain reaction (RT-PCR)-based method is the well recognized detection method for the enormous analytical demands. However, the RT-PCR method typically takes a relatively long time, and can produce false positive and false negative results. Mass spectrometry (MS) is a very commonly used technique with extraordinary sensitivity, specificity and speed, and can produce qualitative and quantitative information of various analytes, which cannot be achieved by RT-PCR. Since the pandemic outbreak, various mass spectrometric approaches have been developed for rapid detection of SARS-CoV-2, including the LC-MS/MS approaches that could allow analysis of several hundred clinical samples per day with one MS system, MALDI-MS approaches that could directly analyze clinical samples for the detection, and efforts for the on-site detection with portable devices. In this review, these mass spectrometric approaches were summarized, and their pros and cons as well as further development were also discussed.

Original languageEnglish
Article number116759
JournalTrAC - Trends in Analytical Chemistry
Volume157
DOIs
Publication statusPublished - Dec 2022

Keywords

  • MALDI
  • Mass spectrometry
  • On-site detection
  • Proteomics
  • SARS-CoV-2

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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